Human kidney proximal tubule cells are vulnerable to the effects of Rauwolfia serpentina

Cell Biology and Toxicology
Miriam E MossobaRobert L Sprando

Abstract

Rauwolfia serpentina (or Snake root plant) is a botanical dietary supplement marketed in the USA for maintaining blood pressure. Very few studies have addressed the safety of this herb, despite its wide availability to consumers. Its reported pleiotropic effects underscore the necessity for evaluating its safety. We used a human kidney cell line to investigate the possible negative effects of R. serpentina on the renal system in vitro, with a specific focus on the renal proximal tubules. We evaluated cellular and mitochondrial toxicity, along with a variety of other kidney-specific toxicology biomarkers. We found that R. serpentina was capable of producing highly detrimental effects in our in vitro renal cell system. These results suggest more studies are needed to investigate the safety of this dietary supplement in both kidney and other target organ systems.

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Citations

Oct 31, 2018·Clinical and Translational Medicine·Yong Zhang
Aug 13, 2020·Dose-response : a Publication of International Hormesis Society·Syed Muhammad Ali ShahJaweria Nisar

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