Apr 14, 2020

Mapping the genetic and environmental aetiology of autistic traits in Sweden and the UK

BioRxiv : the Preprint Server for Biology
Zoe E ReedO. S. P. Davis

Abstract

Autistic traits are influenced by both genetic and environmental factors, and are known to vary geographically in prevalence. But to what extent does their aetiology also vary from place to place? We applied a novel spatial approach to data from two large twin studies, the Child and Adolescent Twin Study in Sweden (CATSS) and the Twins Early Development Study (TEDS) in the UK, to explore how the influence of nature and nurture on autistic traits varies from place to place. We present maps of gene- and environment- by geography interactions that suggest, for example, higher heritability and lower non-shared environmental influence in more densely populated areas. We hope this systematic approach to aetiological interactions will inspire research to identify previously unknown environmental influences on the aetiology of autistic traits.

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Mentioned in this Paper

NRG4 gene
A3GALT2 gene
APOC3 gene
Genome
Genes
Anticoagulants, Oral
Somatomedins
Lipoprotein-associated Phospholipase A2 Assay
Gene Mutation
PLA2G7 gene

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