Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study

BMC Women's Health
Per-Göran LarssonStig Larsen

Abstract

The primary objective of this study was to investigate if supplementary lactobacilli treatment could improve the initial cure rate after vaginal clindamycin therapy, and secondly, if lactobacilli as repeated adjunct treatment during 3 menstrual cycles could lengthen the time to relapse after initial cure. Women (n = 100) with bacterial vaginosis diagnosed by Amsel criteria were after informed consent offered vaginal clindamycin therapy followed by vaginal gelatine capsules containing either 109 freeze-dried lactobacilli or identical placebo capsules for 10 days during 3 menstrual cycles in a double-blind, randomized, placebo-controlled trial. The initial intent to treat (ITT) analysis for the one-month cure rate was 64% in the lactobacilli group and 78% in the placebo group (p > 0.05). However, any patient with missing or unclassified smears at the initial visit who continued the study and whose next smear indicated a cure was included in the cured group; the study also excluded two of the patients in the lactobacilli group who reported that they did not take any vaginal capsules. With consideration to these population changes, the initial cure rate would be 77% in the lactobacilli group. The 76 cured women were followed for 6 ...Continue Reading

References

May 1, 1992·Sexually Transmitted Diseases·A HallénC Påhlson
Jan 1, 1983·British Journal of Hospital Medicine·S G Dawson, J R Harris
Nov 1, 1995·American Journal of Obstetrics and Gynecology·M R JoesoefB Utomo
Feb 24, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M R JoesoefS L Hillier
Aug 1, 2002·Journal of Clinical Microbiology·Alejandra VásquezGöran Molin
Apr 20, 2004·Current Opinion in Infectious Diseases·Phillip E Hay
Apr 1, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Urban ForsumP G Larsson
May 4, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P G LarssonP Wölner-Hanssen
Jul 14, 2005·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P G Larsson, U Forsum
May 2, 2006·American Journal of Obstetrics and Gynecology·Jack D SobelSharon L Hillier
May 20, 2006·BJOG : an International Journal of Obstetrics and Gynaecology·P-G LarssonUNKNOWN Premature study group of the Southeast Health Care Region of Sweden

❮ Previous
Next ❯

Citations

Mar 23, 2012·Archives of Gynecology and Obstetrics·Nemanja StojanovićSnežana Plešinac
Aug 21, 2010·Canadian Journal of Microbiology·Sophie Coudeyras, Christiane Forestier
Jan 29, 2013·BMC Infectious Diseases·Sonal PendharkarHarold Marcotte
Oct 7, 2011·International Journal of Women's Health·Jean-Pierre Menard
Jul 17, 2013·Nutrients·Maria Grazia CagettiGuglielmo Campus
Oct 31, 2013·Archives of Gynecology and Obstetrics·Sandra BorgesPaula Teixeira
Sep 27, 2014·International Journal of Oral Science·Claudia VuottoGianfranco Donelli
Oct 29, 2015·Archives of Gynecology and Obstetrics·Werner MendlingPhilipp Grob
Aug 23, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sedigheh HantoushzadehSedigheh Borna
Nov 4, 2009·Expert Review of Anti-infective Therapy·Hans Verstraelen, Rita Verhelst
Mar 4, 2014·Expert Opinion on Pharmacotherapy·Gilbert G G DondersDace Rezeberga
Nov 18, 2010·Expert Opinion on Pharmacotherapy·Roderick A MacPheeGregor Reid
Dec 27, 2011·Gynécologie, obstétrique & fertilité·J-M Bohbot, J-P Lepargneur
Jun 26, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·T Iannitti, B Palmieri
Nov 28, 2009·Medical Hypotheses·Usha SrinivasanBetsy Foxman
Sep 8, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Guido Lopes Dos Santos SantiagoRita Verhelst
Nov 19, 2015·Journal of Clinical Pathology·Alessandro Di CerboTommaso Iannitti
Mar 16, 2013·FEMS Microbiology Reviews·Kurt Selle, Todd R Klaenhammer
Jan 26, 2012·FEMS Microbiology Reviews·Olaya Rendueles, Jean-Marc Ghigo
Apr 11, 2015·Frontiers in Physiology·Mariya I PetrovaSarah Lebeer
May 25, 2016·Journal of Midwifery & Women's Health·Lisa HansonNasia Safdar
Jul 29, 2011·International Journal of STD & AIDS·J SherrardUNKNOWN European IUSTI
Feb 15, 2011·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Anke Hemmerling, Craig R Cohen
Sep 11, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Gregor ReidWayne Miller
Mar 19, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ibrahim ElsharkawyShymaa Abdelazim Mansour Mansour
Feb 24, 2010·Maternal and Child Health Journal·Debra B StulbergStacy Tessler Lindau
Apr 8, 2020·JAMA : the Journal of the American Medical Association·Amanda L Lewis, Louise C Laurent
Oct 17, 2019·International Journal of Environmental Research and Public Health·Ziyue WangYingjie Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
DNA assay

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Bacterial Vaginosis

Bacterial vaginosis can increase the risk of sexually transmitted infections and in rare cases lead to pelvic inflammatory diseases. Discover the latest research on Bacterial Vaginosis here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.