Human leucocyte antigen alleles confer susceptibility and progression to Graves' ophthalmopathy in a Southern Chinese population.

The British Journal of Ophthalmology
Xiaosheng HuangJun Zhao

Abstract

To evaluate the contributions of human leucocyte antigen (HLA) class I and II genes in the development of Graves' ophthalmopathy (GO) in a Southern Chinese population. Eight HLA loci were genotyped and analysed in 272 unrelated patients with Graves' disease (GD) or the proptosis and myogenic phenotypes of GO, and 411 ethnically matched control subjects. The allele frequencies of HLA-DRB1*16:02 and -DQB1*05:02 in the GD, proptosis and myogenic groups, HLA-B*38:02 and -DQA1*01:02 in the myogenic group were significantly higher than those in the control group, respectively (all corrected p values <0.05, OR >2.5). The haplotype frequencies of HLA-DRB1*16:02-DQA1*01:02-DQB1*05:02 and HLA-DRB1*16:02-DQA1*01:02-DQB1*05:02-DPA1*02:02-DPB1*05:01 in the proptosis and myogenic groups, and HLA-A*02:03-B*38:02-C*07:02 and HLA-A*02:03-B*38:02-C*07:02-DRB1*16:02-DQA1*01:02-DQB1*05:02-DPA1*02:02-DPB1*05:01 in the myogenic group were significantly higher than those in the control group respectively (all corrected p values <0.05, OR >2.5). The potential epitopes ('FLGIFNTGL' of TSHR, 'IRHSHALVS', 'ILYIRTNAS' and 'FVFARTMPA' of IGF-1R) were fitted exactly in the peptide-binding groove between HLA-DRA1-DRB1*16:02 heterodimer, and the epitopes ('IL...Continue Reading

References

Nov 1, 1986·Clinical Endocrinology·M FreckerN R Farid
Nov 1, 1988·Genetics·R C Lewontin
Dec 22, 1998·American Journal of Ophthalmology·K Ohtsuka, Y Nakamura
Jul 5, 2005·Human Immunology·Myoung Hee ParkBo Youn Cho
Sep 28, 2006·Human Immunology·Christina E M Voorter, Ella M van den Berg-Loonen
Mar 21, 2008·Thyroid : Official Journal of the American Thyroid Association·Patricia Mitiko Santello AkaishiEduardo Antonio Donadi
Sep 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanli TsuiTerry J Smith
Sep 4, 2009·Thyroid : Official Journal of the American Thyroid Association·Hidefumi InabaLeslie J De Groot
Feb 26, 2010·The New England Journal of Medicine·Rebecca S Bahn
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Jun 2, 2012·Current Genomics·Omid KhalilzadehAliakbar Amirzargar
Apr 18, 2013·Endocrinology·Hidefumi InabaLeslie J De Groot
Mar 22, 2014·Investigative Ophthalmology & Visual Science·Yao Wang, Terry J Smith
Jan 7, 2015·Nature Reviews. Endocrinology·Terry J Smith
Sep 8, 2016·Frontiers in Endocrinology·Hidefumi InabaTakashi Akamizu
Dec 28, 2016·Annals of Neurology·Tae-Joon KimKon Chu
Jun 20, 2017·Journal of Molecular Graphics & Modelling·Manijeh MahdaviMajid Kheirollahi
Jan 3, 2018·Nature Reviews. Immunology·Calliope A DendrouLars Fugger
Jan 10, 2018·Immunology·Kamilla Kjaergaard JensenMorten Nielsen
Jan 15, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Yaqing ShuXinhua Yu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.