PMID: 9419454Jan 7, 1998Paper

Human leukemia-derived dendritic cells: ex-vivo development of specific antileukemic cytotoxicity

Critical Reviews in Immunology
A ChoudhuryD F Claxton

Abstract

The human myeloid leukemias are a diverse group of disorders characterized by massive clonal expansion of myeloid cells showing variable degrees of differentiation block. Leukemic dendritic cells were generated in culture from chronic myelogenous leukemia (CML). These were used to stimulate autologous T cells to develop leukemia-specific cytotoxicity. Available data suggest that the cells responsible for the cytolytic activity are at least in part CD8+ and HLA restricted in their function. Additional data suggest that some anti-CML cellular activity may be Fas mediated. T-cell receptor studies provide evidence for an oligoclonal response implying a recognition of a limited number of antigens. We have used culture techniques similar to those used for CML to study the ability of AML cells to differentiate toward dendritic cells. Four of five patients have shown acute leukemia-derived dendritic cells. This work offers an avenue for the development of novel strategies for the control of human myeloid leukemias.

Citations

Dec 5, 2002·International Journal of Hematology·Hee-Je KimChun-Choo Kim
Mar 22, 2002·The Lancet Oncology·M JeffordI D Davis
Dec 1, 2001·Expert Opinion on Biological Therapy·R F RousseauH E Heslop
May 27, 2006·Experimental Hematology·Anja MoldenhauerAbdulgabar Salama
Jul 22, 2010·Cancer Biology & Therapy·Nikki KeaseyDavid F Claxton
Mar 21, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Theresia M WestersArjan A van de Loosdrecht
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