Human leukocyte antigen-A, -B and -C alleles and human leukocyte antigen haplotypes in Turkey: relationship to other populations

Tissue Antigens
F A UyarG Saruhan-Direskeneli

Abstract

In this study, we present, for the first time, human leukocyte antigen (HLA) class I allele and haplotype frequencies at the DNA level in a sample of 142 donors from Turkey. HLA typing was performed by medium-to-high resolution polymerase chain reaction sequence-specific oligonucleotide probes method. The most frequent HLA alleles at class I locus were A*0201(0.257), -B*35(0.204) and -Cw*04(0.173). A*0201-B*35-Cw*04(0.056) was the most common three-locus haplotype. Allele and haplotype frequency comparisons and neighbour-joining dendrograms, constructed using DA genetic distances and correspondence analysis using HLA-A, -B and -C, and -DRB1 allele frequencies, revealed similarities with other Mediterranean and European populations, but not with Mongol populations. These results agree with previous studies and confirm that the present day Turkish population is genetically more similar to its geographic neighbours than its historical neighbours in central Asia. The comprehensive HLA data on the Turkish population at the DNA level including up to six-locus putative haplotypes generated in this study will be useful for further studies.

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Citations

Jan 14, 2011·Rheumatology International·Necati CakırMustafa Senocak
Apr 15, 2006·Digestive Diseases and Sciences·F Aytül UyarGüher Saruhan-Direskeneli
Oct 17, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Bahar KelesBedri Ozer
Jan 11, 2011·The Journal of Infectious Diseases·Aimee MerinoRichard A Kaslow
Jan 1, 2014·Human Immunology·Zorana AndricRuzica Simonovic
Jan 15, 2009·Renal Failure·Gonca Emel KarahanMahmut Nezih Carin
Mar 26, 2013·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Gurkan MertCan Polat Eyigun
Nov 18, 2009·Transplantation Proceedings·G E KarahanM N Carin
Aug 30, 2008·Tissue Antigens·Md Eunus AliMd Hafizur Rahman
Jan 3, 2013·International Journal of Dermatology·Cilem Kaya KocOlcay Yegin
May 25, 2006·Human Immunology·Güher Saruhan-DireskeneliFeza Deymeer
Jul 9, 2013·American Journal of Human Genetics·Güher Saruhan-DireskeneliAmr H Sawalha
Mar 30, 2017·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Zühre KayaEnes Değirmenci
May 7, 2020·Immunological Investigations·Begum OzbekIlhan Tezcan

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