Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry

Journal of Immunology Research
Mqondisi TshabalalaMichael S Pepper

Abstract

Human leukocyte antigen- (HLA-) A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 allele and haplotype frequencies were studied in a subset of 237 volunteer bone marrow donors registered at the South African Bone Marrow Registry (SABMR). Hapl-o-Mat software was used to compute allele and haplotype frequencies from individuals typed at various resolutions, with some alleles in multiple allele code (MAC) format. Four hundred and thirty-eight HLA-A, 235 HLA-B, 234 HLA-DRB1, 41 HLA-DQB1, and 29 HLA-C alleles are reported. The most frequent alleles were A∗02:02g (0.096), B∗07:02g (0.082), C∗07:02g (0.180), DQB1∗06:02 (0.157), and DRB1∗15:01 (0.072). The most common haplotype was A∗03:01g~B∗07:02g~C∗07:02g~DQB1∗06:02~DRB1∗15:01 (0.067), which has also been reported in other populations. Deviations from Hardy-Weinberg equilibrium were observed in A, B, and DRB1 loci, with C~DQB1 being the only locus pair in linkage disequilibrium. This study describes allele and haplotype frequencies from a subset of donors registered at SABMR, the only active bone marrow donor registry in Africa. Although the sample size was small, our results form a key resource for future population studies, disease association studies, and donor recruitment strategies.

References

Feb 24, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·J H LaverM R Abboud
Jan 15, 2003·Annual Review of Medicine·Mary Carrington, Stephen J O'Brien
Mar 2, 2005·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Ernette D du ToitTerry E-A Schlaphoff
Jun 7, 2005·Human Immunology·Pierre-Antoine GourraudAnne Cambon-Thomsen
Jun 7, 2005·Current Biology : CB·Franck PrugnolleFrançois Balloux
Jun 17, 2006·Current Opinion in Immunology·Christian BranderBruce D Walker
Apr 21, 2007·Tissue Antigens·C K HurleyM Oudshoorn
Aug 29, 2007·Bone Marrow Transplantation·A H SchmidtC Rutt
Dec 12, 2007·Bone Marrow Transplantation·A H SchmidtC Rutt
Aug 5, 2008·Current Opinion in Immunology·Effie W Petersdorf
Sep 12, 2008·Transfusion Medicine·K A JohansenUNKNOWN Council on Science and Public Health, American Medical Association
Oct 8, 2008·Nucleic Acids Research·James RobinsonSteven G E Marsh
Jul 31, 2010·Tissue Antigens·E C CastelliE A Donadi
Apr 13, 2011·Immunology·Alicia Sanchez-MazasErik Thorsby
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Jun 15, 2011·The AAPS Journal·Inna G Ovsyannikova, Gregory A Poland
Nov 6, 2012·American Journal of Physical Anthropology·Todd R Disotell
Aug 30, 2013·International Journal of Circumpolar Health·Stephanie MetcalfePaul Brassard
Sep 17, 2013·Tissue Antigens·G BarbujaniF Tassi
Jul 24, 2014·The New England Journal of Medicine·Loren GragertMartin Maiers
Sep 26, 2014·Journal of Immunology Research·Heike Kunze-SchumacherChristina Bade-Doeding
Nov 22, 2014·Nucleic Acids Research·James RobinsonSteven G E Marsh
Sep 9, 2015·Journal of Immunology Research·Mqondisi TshabalalaMichael S Pepper

❮ Previous
Next ❯

Citations

Sep 23, 2020·Archives of Pathology & Laboratory Medicine·Anastasia GandiniElizabeth Mayne

❮ Previous
Next ❯

Software Mentioned

Mat
Hapl
EasyMatch®
OptiMatch
Arlequin
NMDP HapLogic

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.