Human leukocyte antigen association in idiopathic thrombotic thrombocytopenic purpura: evidence for an immunogenetic link

Journal of Thrombosis and Haemostasis : JTH
M A ScullyS J Machin

Abstract

Thrombotic thrombocytopenic purpura (TTP) is a rare, acute, life-threatening disorder, associated with a deficiency in ADAMTS 13. The majority of acute, idiopathic, adult TTP cases are associated with anti-ADAMTS 13 IgG antibodies. However, the factor(s) precipitating an acute TTP episode are not always obvious; indeed, a multifactorial etiology is likely. DNA was used for human leukocyte antigen (HLA) class II typing, using polymerase chain reaction (PCR)-sequence-specific primer and PCR-sequence-specific oligonucleotide probe to methodology to investigate 50 European acquired idiopathic TTP cases. There was an increase in the frequency of HLA-DQB1*0301 (HLA-DQ7) in patients with TTP as compared with controls [58.0% vs. 34.5% (P=0.048)]. The frequencies of HLA-DRB1*11 and HLA-DRB3* were also significantly increased in TTP patients as compared with controls [44.0% vs. 12.0% (P=0.0024) and 84.0% vs. 58.0% (P=0.024)], although it remains uncertain whether susceptibility is influenced by HLA-DQ or HLA-DR molecules or other genes in this haplotype. The frequencies of HLA-DRB1*04 and HLA-DRB4 (HLA-DR53) were significantly decreased in the patient group as compared with controls [10.0% vs. 35.0% and 26.0% vs. 61.5% (P=0.0096 and P=0....Continue Reading

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Citations

Feb 28, 2013·Hämostaseologie·M SchallerJ A Kremer Hovinga
Sep 13, 2014·Blood Reviews·Fabian C VerbijNicoletta Sorvillo
Feb 10, 2012·La Presse médicale·Paul Coppo
Oct 2, 2015·EBioMedicine·Jan VoorbergRob Fijnheer
Jun 8, 2011·Journal of Clinical Apheresis·Amandine SevyPierre-Jean Weiller
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·X L Zheng
May 4, 2011·Journal of Thrombosis and Haemostasis : JTH·W PosJ Voorberg
Oct 15, 2013·Journal of Clinical Apheresis·Jay S RavalJoseph E Kiss
Aug 22, 2015·European Journal of Internal Medicine·Antoine FroissartUNKNOWN French Reference Center for Thrombotic Microangiopathies
Dec 31, 2014·La Revue de médecine interne·G SauvètreY Benhamou
Apr 21, 2012·Blood·Johanna A Kremer Hovinga, Jan Voorberg
Jul 8, 2016·PloS One·Suella MartinoUNKNOWN French Reference Center for Thrombotic Microangiopathies
Oct 21, 2016·Journal of Thrombosis and Haemostasis : JTH·I ManciniUNKNOWN Italian Group of TTP Investigators
Oct 28, 2017·British Journal of Haematology·Anna M LombardiFabrizio Vianello
Jan 23, 2018·Journal of Thrombosis and Haemostasis : JTH·J A Kremer HovingaM Schaller
Apr 7, 2017·Nature Reviews. Disease Primers·Johanna A Kremer HovingaKaren Vanhoorelbeke
Nov 1, 2016·Personalized Medicine·Li Zhang
Dec 14, 2018·Journal of Pediatric Hematology/oncology·Ali Amin AsnafiNajmaldin Saki
May 28, 2011·British Journal of Haematology·Mari R ThomasMarie A Scully
Nov 22, 2016·Journal of Thrombosis and Haemostasis : JTH·M ScullyUNKNOWN International Working Group for Thrombotic Thrombocytopenic Purpura
Feb 6, 2021·Journal of Clinical Medicine·Senthil SukumarSpero R Cataland
Feb 20, 2021·Hämostaseologie·Gaëlle BécelPaul Coppo

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