Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Abdulbaqi Al-TomaChris J Mulder

Abstract

Celiac disease (CD) is a common gluten-sensitive enteropathy associated with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. The aim of this study was to determine if a particular HLA-DQ subtype predisposes to complications such as refractory CD with (RCD II) or without aberrant T cells (RCD I), and enteropathy-associated T-cell lymphomas (EATL). Molecular HLA-DQ typing was performed on 43 RCD I, 43 RCD II, and 30 EATL patients, and compared with age-matched groups of 121 patients with histologically defined uncomplicated CD and 183 healthy controls. All individuals were Dutch Caucasians and were at least 21 years of age. HLA-DQ2 was present in 79% of RCD I, 97.7% of RCD II, and 96.6% of EATL patients. The differences were significant when compared with 28.9% in controls but not with 91.7% in uncomplicated CD. Homozygosity for HLA-DQ2 was observed in 25.5% of RCD I, 44.1% of RCD II, and 53.3% of EATL patients vs 20.7% of uncomplicated CD patients and 2.1% of controls. HLA-DQ8 was present in 10.7% of CD, 16.2% of RCD I, 9.3% of RCD II, and 6.6% of EATL patients vs 20.2% of controls. Homozygosity for HLA-DQ2 is associated with RCD II and EATL. Early identification of HLA-DQ2 homozygous CD patients may help to recognize CD patients...Continue Reading

References

Jan 1, 1989·The Journal of Experimental Medicine·L M SollidE Thorsby
Oct 1, 1995·The Journal of Pathology·P G Isaacson
Apr 2, 1998·Journal of Pediatric Gastroenterology and Nutrition·L GrecoF Clerget-Darpoux
Apr 21, 1998·Human Immunology·A PolviJ Partanen
Aug 10, 2000·Histopathology·N Patey-Mariaud De SerreN Brousse
Jun 9, 2001·European Journal of Gastroenterology & Hepatology·F Biagi, G R Corazza
Sep 28, 2002·Science·Lu ShanChaitan Khosla
Sep 3, 2003·Alimentary Pharmacology & Therapeutics·M S GoerresC J J Mulder
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Willemijn VaderFrits Koning
Jun 1, 2005·Best Practice & Research. Clinical Gastroenterology·Severin DaumChris J J Mulder
Nov 5, 2005·Acta Haematologica·Alan Tyndall, Thomas Daikeler

❮ Previous
Next ❯

Citations

Jul 20, 2012·Seminars in Immunopathology·Georgia MalamutNadine Cerf-Bensussan
Nov 10, 2007·Current Gastroenterology Reports·Hani AbdallahCiarán P Kelly
Aug 15, 2013·Current Opinion in Oncology·Georgia Malamut, Christophe Cellier
Sep 11, 2007·Digestive Diseases·A Al-tomaC J J Mulder
Jan 25, 2012·Blood·Antonio Di SabatinoGino R Corazza
Jan 7, 2014·PloS One·Federico BiagiGino R Corazza
Dec 14, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Francesca MegiorniMaria Cristina Mazzilli
Jun 3, 2011·World Journal of Gastroenterology : WJG·Hugh James FreemanAlan Br Thomson
Nov 17, 2012·World Journal of Gastroenterology : WJG·Naiyana GujralAlan B R Thomson
Nov 26, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Federico BiagiGino R Corazza
Jul 28, 2010·Immunogenetics·Jennifer May-Ling TjonFrits Koning
Jan 12, 2011·Annual Review of Immunology·Valérie AbadieBana Jabri
Jul 12, 2008·Scandinavian Journal of Gastroenterology·Wieke H M VerbeekVeerle M H Coupé
Nov 26, 2015·Expert Review of Gastroenterology & Hepatology·Abdul R RishiJoseph A Murray
Mar 1, 2008·Expert Review of Clinical Immunology·Wieke H M VerbeekChris J J Mulder
Feb 8, 2014·Expert Review of Gastroenterology & Hepatology·Georgia Malamut, Christophe Cellier
Apr 1, 2008·Expert Opinion on Medical Diagnostics·Jihane RomanosMartin C Wapenaar
Feb 19, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joseph A MurrayChristine E McLaren
Oct 23, 2012·Gastrointestinal Endoscopy Clinics of North America·Sonia S Kupfer, Bana Jabri
Oct 23, 2012·Gastrointestinal Endoscopy Clinics of North America·Georgia MalamutChristophe Cellier
Sep 2, 2011·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ola OlénKarin Ekström Smedby
Sep 21, 2010·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Thorvardur R HalfdanarsonDavid J Inwards
Mar 9, 2010·Best Practice & Research. Clinical Gastroenterology·Jolanda M W van de WaterChris J J Mulder
Nov 26, 2008·Human Immunology·Francesca MegiorniMaria Cristina Mazzilli
Oct 9, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Joseph A MurrayAlbert J Czaja
Oct 31, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Victorien M WoltersChris J J Mulder
May 29, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·R CiccocioppoG R Corazza
Aug 15, 2008·Histopathology·C Ho-YenP Ciclitira
Aug 2, 2008·Alimentary Pharmacology & Therapeutics·M L HainesP R Gibson
Dec 6, 2006·Human Immunology·Elise EllerPamela R Fain
Sep 15, 2006·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A Tursi, C D Inchingolo
Sep 9, 2015·Nature Reviews. Gastroenterology & Hepatology·Tom van GilsChris J J Mulder
Feb 27, 2015·American Journal of Hematology·Petula NijeboerGerd Bouma
Aug 6, 2015·Genome Medicine·Gad AbrahamMichael Inouye
Jun 11, 2015·Best Practice & Research. Clinical Gastroenterology·Georgia Malamut, Christophe Cellier
May 17, 2015·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Nicolette J WierdsmaChris J J Mulder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Victorien M WoltersChris J Mulder
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Abdulbaqi Al-TomaChris J Mulder
Lancet
Peter H Green, Bana Jabri
© 2021 Meta ULC. All rights reserved