Human leukocyte antigen-DRB1 polymorphism in childhood acute lymphoblastic leukemia

Molecular and Clinical Oncology
Mervat M El AnsaryAlshymaa A Ahmed

Abstract

Similar to autoimmune diseases, there are clear associations between resistance or susceptibility to cancer and the classic human leukocyte antigen (HLA) profile of an individual. HLA-associated susceptibility to childhood acute lymphoblastic leukemia (ALL) may provide clues to leukemogenesis in general and to the role of other risk factors. The present study aimed to determine the association between the HLA-DRB1 genotype and susceptibility to ALL in children and to assess the prognostic value of HLA-DRB1 alleles in these patients. This study included 50 ALL patients who were consecutively admitted to the Pediatric Oncology Unit of Zagazig University Hospital and 50 gender-matched healthy volunteers as a control group. The patients were subjected to full clinical history, thorough clinical examination and routine laboratory investigations. Molecular HLA-DRB1 typing for patients and controls using the reverse sequence-specific oligonucleotide probe technique was performed. HLA-DRB1*04 allele frequency was significantly higher in female patients compared to that in female controls (P=0.03) and in patients aged <10 years compared to those aged ≥10 years at the time of diagnosis (P=0.01). HLA-DRB1*11 allele frequency was significa...Continue Reading

References

Nov 1, 1980·Tissue Antigens·V E von FliednerM Jeannet
Nov 1, 1983·Human Immunology·V E Von FliednerM Wyss
Mar 1, 1996·British Journal of Cancer·S P DeardenW G Bardsley
Oct 13, 2000·BMJ : British Medical Journal·B Christie
Mar 28, 2002·Human Immunology·Ritika JainiNarinder K Mehra
Dec 11, 2002·British Journal of Haematology·Seisho TakeuchiH Phillip Koeffler
Oct 15, 2009·Hematology/oncology Clinics of North America·Josep-Maria Ribera, Albert Oriol
Jan 12, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ching-Hon PuiRobert J Arceci
Feb 12, 2011·The Journal of International Medical Research·K OzdilliG Gedikoglu
Sep 6, 2013·International Journal of Immunogenetics·W M Howell

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.