Human leukocyte antigen E in human cytomegalovirus infection: friend or foe?

Acta Biochimica Et Biophysica Sinica
Fang GongHong Jiang

Abstract

Human cytomegalovirus (HCMV) is a well-studied β-herpesvirus virus, which adopts a variety of strategies to evade immune surveillance. It has been reported that in HCMV-infected cells, classical major histocompatibility (MHC) class I molecules are down-regulated, but the MHC class Ib molecule human leukocyte antigen (HLA)-E is normally expressed or even overexpressed on the cell surface. HLA-E has been first described to interact with CD94/NKG2 receptors expressed mainly on the surface of natural killer (NK) cells, thus confining its role to the regulation of NK-cell function. The engagement of CD94/NKG2A with HLA-E, with a signal peptide of the HCMV glycoprotein UL40, usually induces inhibitory signals. However, HLA-E also serves as a ligand for the TCR expressed by αβCD8(+) T cells. Recognition of peptides presented by HLA-E may result in CD8(+) effector T-cell activation. These findings will help to understand more on both pathogenic and protective roles of HLA-E in HCMV infection. In this review, we discussed recent studies about the roles of HLA-E in HCMV infection.

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Citations

Dec 9, 2017·Frontiers in Endocrinology·Allison L Bayer, Christopher A Fraker
Sep 3, 2016·Oncotarget·Barbara SeligerArndt Hartmann
Jan 16, 2014·Indian Journal of Virology : an Official Organ of Indian Virological Society·B M PratheekSubhasis Chattopadhyay
Jan 23, 2018·Frontiers in Immunology·Roberta RovitoAnn C T M Vossen

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