Human leukocyte antigen expression in paired primary lung tumors and brain metastases in non-small cell lung cancer.

Cancer Immunology, Immunotherapy : CII
Jarrett J FailingAaron S Mansfield

Abstract

Loss of human leukocyte antigen (HLA) class 1 expression is a mechanism of tumor immune escape and may contribute to resistance to immunotherapy. Patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors can have discordant responses between brain metastases and extracranial sites of disease. We sought to evaluate whether HLA class 1 expression was retained in metastatic NSCLC. Patients with paired primary NSCLC and brain metastases were identified from our institution's tissue registry. HLA class 1 cell membrane expression on tumor cells was determined by immunohistochemistry. Tumors with greater than the median of 10% HLA expression were considered positive. Agreement statistics (κ) were used to assess the congruence of HLA expression. 51 patients with paired primary NSCLC and brain lesions were identified. The median HLA class 1 expression was 20% in the primary tumors (IQR 0-65%) and 10% in the brain metastases (IQR 5-40%). 27 primary tumors and 24 brain metastases were positive for HLA expression. There was disagreement in HLA positivity between paired lesions in 11 patients (22%, 95% CI 12-35%) (κ = 0.57, 95% CI 0.35-0.79) (p = 0.0001). None of the patients received checkpoint inhibitors f...Continue Reading

References

Aug 19, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M RiihimäkiK Hemminki
Nov 7, 2017·Cell·Nicholas McGranahanUNKNOWN TRACERx Consortium
Feb 3, 2018·Scientific Reports·Aaron S MansfieldJin Jen
Mar 24, 2018·Current Opinion in Immunology·Natalia AptsiauriFederico Garrido
Feb 20, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lizza E L HendriksBenjamin Besse

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Citations

Mar 9, 2021·Cancer Metastasis Reviews·Shelby M KnocheJoyce C Solheim
Apr 17, 2021·Cancer Metastasis Reviews·Ignacio AlgarraAngel M Garcia-Lora

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