PMID: 20646443Jul 22, 2010Paper

Human leukocyte antigen-G 14 bp deletion polymorphism in severe pre-eclampsia

Zhonghua fu chan ke za zhi
Zhan ZhangShou-hua Rong

Abstract

To investigate the relationship between human leukocyte antigen-G (HLA-G) gene Exon 8 14 bp deletion polymorphism and the pathogenesis of severe pre-eclampsia. Forty-two pregnant women with severe pre-eclampsia, who admitted to the Third Affiliated Hospital of Zhengzhou University from October 2008 to February 2009, and their newborns were chosen as the severe pre-eclampsia group. Another 45 healthy gravidas at the third trimester and their newborns were chosen as the control. All gravidas in both groups were Han Nationality. HLA-G Exon 8 genotyping was detected by PCR in both groups and the allele frequencies and genotype frequencies were compared between the two groups. The genotype frequencies of maternal-neonatal pairs were also analyzed. (1) In the severe pre-eclampsia group, 14% of the maternal-neonatal pairs were homozygote of 14 bp deletion, and significantly higher frequency 33% (15/45) was found in the control group (P=0.038). (2) No significant difference was found in the allele frequencies and genotype frequencies of HLA-G 14 bp deletion polymorphism among all the mothers between the two groups (P>0.05). (3) The +14 bp and -14 bp allele frequencies of HLA-G 14 bp deletion polymorphism in newborns in the severe pre-e...Continue Reading

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