Human leukocyte antigen-G allele polymorphisms have evolved following three different evolutionary lineages based on intron sequences

Human Immunology
Isabel CerveraJ Martínez-Laso

Abstract

Human leukocyte antigen (HLA)-G alleles follow a different pattern of polymorphism generation from those of the HLA classical I alleles. These polymorphisms have been defined as a result of random permitted point mutations in exons. However, this polymorphism maintenance could have an evolutionary specific pathways based on noncoding regions as introns, 14-bp deletion/insertion (exon 8), or promoter regions. Therefore a systematic sequencing study of HLA-G alleles was done obtaining the complete genomic sequence of 16 different HLA-G alleles: nine alleles were intron and exon confirmatory sequences, four were exon confirmatory and new intron described sequences, and three were new alleles. A 14-bp deletion/insertion polymorphism was also sequenced in these alleles. These sequences, together with those previously published, were compared, and phylogenetic and molecular evolutionary analyses were performed. Results showed the presence of three major specific evolutionary patterns, tentatively named lineages, and the other four as minor lineages (only one allele). The relative age of the major lineages could also be established based on the number of lineage-specific positions and the number of alleles of each lineage. Two main me...Continue Reading

References

Apr 13, 1990·Science·S KovatsR DeMars
Sep 1, 1995·British Journal of Obstetrics and Gynaecology·K E HumphreyB J Trudinger
Jan 1, 1993·Immunogenetics·P MoralesA Arnaiz-Villena
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella
Nov 5, 1997·American Journal of Reproductive Immunology : AJRI·A HammerG Dohr
Feb 17, 1998·European Journal of Immunology·A BlaschitzG Dohr
Mar 19, 1999·Tissue Antigens·V RebmannH Grosse-Wilde
Apr 6, 1999·The Journal of Experimental Medicine·S Rajagopalan, E O Long
May 13, 1999·Immunological Reviews·P Le Bouteiller, A Blaschitz
Jul 28, 1999·International Immunology·F A Le GalN Rouas-Freiss
Sep 9, 1999·Journal of Reproductive Immunology·M KirszenbaumE D Carosella
Sep 9, 1999·Journal of Reproductive Immunology·I Khalil-DaherN Rouas-Freiss
May 30, 2001·Transplantation Proceedings·B RiteauE D Carosella
Jan 9, 2003·European Journal of Immunology·Corinne SolierPhilippe Le Bouteiller
Jan 10, 2003·Nucleic Acids Research·James RobinsonSteven G E Marsh
Jan 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Philippe MoreauEdgardo D Carosella
Feb 27, 2004·Immunogenetics·Jorge Martinez-LasoAntonio Arnaiz-Villena
Mar 11, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·S G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Mar 26, 2004·Human Immunology·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Sep 21, 2004·Bioinformatics·D P MartinD Posada
Oct 21, 2005·Human Molecular Genetics·Zheng TanCarole Ober
Feb 3, 2006·Tissue Antigens·J Martínez-LasoA Arnaiz-Villena
Apr 14, 2006·Neoplasia : an International Journal for Oncology Research·Frédéric GrosLaurence Amiot
Apr 21, 2007·Tissue Antigens·A Arnaiz-VillenaJ Moscoso

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Citations

Aug 16, 2013·Molecular Biology and Evolution·Kaisson E SantosErick C Castelli
Mar 8, 2011·Human Immunology·Jorge Martínez-LasoIsabel Cervera
Mar 11, 2011·Tissue Antigens·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System

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