Human leukocyte antigen polymorphism in chronic and aggressive periodontitis among Caucasians: a meta-analysis

Journal of Clinical Periodontology
Jamal M SteinS Reichert

Abstract

Multiple studies have reported associations between periodontitis and particular human leukocyte antigens (HLA). Because associations are inconsistent, we conducted a systematic literature review and a meta-analysis focusing on Caucasian case-control studies. A literature search reporting on the distribution of HLA class I and II phenotypes in Caucasian patients with chronic periodontitis (CP) and aggressive periodontitis (AP) was performed. Data sources included electronic databases and bibliographies of published articles. Screening and data abstraction were conducted independently by different reviewers. Out of 174 publications, 12 studies were considered to be suitable for meta-analysis. In patients with CP, no significant HLA associations were found. Patients with AP showed a positive association with HLA-A9 [odds ratio=2.59 (95% confidence interval 1.36-4.83), p=0.004] and HLA-B15 [1.90 (1.15-3.16), p=0.01] as well as a negative association with HLA-A2 [0.72 (0.56-0.94), p=0.01] and -B5 [0.49 (0.30-0.79), p=0.004]. On grouping all patients into one periodontitis group (AP+CP), the same deviations were confirmed with higher statistical significance. For HLA-A9 and -B15, significant heterogeneity was found between the studi...Continue Reading

References

May 1, 1975·Tissue Antigens·P I TerasakiA I Chasens
Oct 1, 1977·Journal of Dental Research·J ReinholdtA Svejgaard
Apr 1, 1992·Journal of Periodontology·S S Socransky, A D Haffajee
Oct 1, 1991·Journal of Periodontology·H Löe, L J Brown
Feb 1, 1988·Tissue Antigens·A AmerA E Dolby
Mar 1, 1986·Journal of Dental Research·R B CogenR A Rasmussen
Sep 1, 1986·Tissue Antigens·P T KloudaR M Davies
Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Mar 1, 1980·Journal of Periodontal Research·M P CullinanG J Seymour
Mar 1, 1984·Journal of Periodontology·D Goteiner, M J Goldman
May 1, 1994·Tissue Antigens·J H MosesJ G Bodmer
Jan 1, 1993·Annual Review of Cell Biology·M R Jackson, P A Peterson
Jun 1, 1996·Journal of Clinical Periodontology·E FiratliO Tuncer
Nov 1, 1996·Annals of Periodontology·P N Papapanou
Dec 9, 1997·Journal of Dental Research·J K DyerK D Patil
Jun 1, 1997·Periodontology 2000·T C Hart, K S Kornman
May 3, 2000·Journal of Periodontal Research·A Contreras, J Slots
Jun 23, 2000·Annals of Periodontology·G C Armitage
Jun 23, 2000·Annals of Periodontology·T F Flemmig
Jun 23, 2000·Annals of Periodontology·M S Tonetti, A Mombelli
Dec 29, 2000·Journal of Periodontology·B S MichalowiczH A Schenkein
Jan 13, 2001·Oral Microbiology and Immunology·A ContrerasJ Slots
May 24, 2001·Journal of Bacteriology·B J PasterF E Dewhirst
Jul 17, 2001·Periodontology 2000·W M Jenkins, P N Papapanou
Aug 9, 2001·Journal of Clinical Periodontology·J J KammaJ Slots
May 16, 2002·Periodontology 2000·Sigmund S Socransky, Anne D Haffajee
Apr 29, 2003·Journal of Clinical Periodontology·Joanna J Kamma, Jørgen Slots
Sep 16, 2004·Journal of Clinical Periodontology·Joanna J KammaAndrea Mombelli
Apr 28, 2005·Periodontology 2000·Jørgen Slots
Dec 2, 2006·The Journal of Evidence-based Dental Practice·Jan Bergström
Jan 12, 2007·Periodontology 2000·Huanxin MengYibing Zhao

❮ Previous
Next ❯

Citations

Jan 26, 2012·Mucosal Immunology·D FarquharsonS Culshaw
Jul 30, 2014·PloS One·Matti MauramoTuomas Waltimo
Dec 15, 2011·Journal of Oral Science·Giselle P GomesRodrigo V Soares
Oct 1, 2008·Journal of Clinical Periodontology·Anna LouropoulouBruno G Loos
Jan 16, 2013·Journal of Periodontal Research·M Mousavi JaziA A Amirzargar
Nov 21, 2012·Journal of Clinical Periodontology·Jamal M SteinSimone Scheithauer
Jun 12, 2013·Journal of Clinical Periodontology·Luigi Nibali
Mar 28, 2013·Geriatrics & Gerontology International·Rupali Agnihotri, Sumit Gaur
Dec 11, 2013·Periodontology 2000·Annsofi JohannsenAnders Gustafsson
Sep 20, 2015·Clinical Oral Implants Research·Stefan Renvert, Marc Quirynen
Aug 26, 2015·Clinical Oral Investigations·Jamal M SteinStefan Reichert
Sep 5, 2012·Acta Odontologica Scandinavica·Letícia Grando MattuellaLetícia Algarves Miranda
Sep 5, 2015·Mediators of Inflammation·Emília Ângela SippertAna Maria Sell
Nov 5, 2016·Molecular Oral Microbiology·L CampbellS Culshaw
Oct 19, 2016·Journal of Clinical Periodontology·Luigi NibaliAlexandre R Vieira
Oct 5, 2018·Journal of Periodontal Research·Luisa ZupinAntonietta Robino
Apr 12, 2013·Periodontology 2000·Robert J Genco, Wenche S Borgnakke
Sep 15, 2019·Acta Odontologica Scandinavica·Letícia Grando MattuellaLetícia Algarves Miranda
Oct 13, 2019·British Dental Journal·Isabel Lopez-OlivaIain Chapple
Oct 18, 2020·Experimental Hematology·João BotelhoFrancesco D'Aiuto
Jan 13, 2015·The Journal of Contemporary Dental Practice·Solomon Olusegun NwhatorOsagie Ikponmwosa
Aug 28, 2021·Clinical and Experimental Dental Research·Matti MauramoTuomas Waltimo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.