Human leukocyte interferon-alpha in cream for the treatment of genital herpes in Asian males. A placebo-controlled, double-blind study

Dermatology : International Journal for Clinical and Investigative Dermatology
T A SyedM M Kahlon

Abstract

Genital herpes simplex virus infection, a sexually transmitted disease, is the commonest cause of ulcerative genital infections among the young and adult population. The recurrent nature of the disease, possible cause of cervical dysplasia and neonatal herpes are the primary concern associated with this infection. The purpose of this double-blind, placebo-controlled study was to evaluate the clinical efficacy and tolerance of human leukocyte inferon-alpha in hydrophilic cream (2x10(6)IU/g) to cure patients afflicted with first episodes of genital herpes. Patients (n = 60), aged 18-40 years (mean: 22.8) with culture-confirmed diagnosis of herpes simplex genitalis, harboring 751 lesions (mean: 12.5) were randomly allocated to two parallel groups (active/placebo). Patients entered the study within 7 days (mean:4.2) of the onset of lesions. Each patient received a precoded 40-gram tube with instructions to apply the trial medication (at home) on their lesions thrice daily for 5 consecutive days (max. 15 topical applications/week). To assess the clinical efficacy patients were examined twice a week. A completely reepithelized lesion with persistent erythema was evaluated as healed or cured. Patients cured during the subsequent treat...Continue Reading

Citations

Jul 14, 2010·International Journal of Dermatology·Martha H VieraBrian Berman
Dec 28, 2006·Journal of the American Academy of Dermatology·David I SmithMichael P Heffernan
Mar 27, 2002·Clinics in Geriatric Medicine·Mervyn L Elgart
Aug 31, 2016·The Cochrane Database of Systematic Reviews·Rachel HeslopVanessa Jordan

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