PMID: 6167482Aug 1, 1981Paper

Human leukocyte interferon treatment of two children with insulin dependent diabetes

Diabetologia
K H RandT C Merigan

Abstract

Two patients with newly diagnosed insulin dependent diabetes mellitus were treated with human leukocyte interferon based on the hypothesis that the diabetes was induced by an active viral infection in the pancreatic islets and could be arrested. High peak levels of serum interferon were achieved (100-200 U/ml) with minimal systemic side effects. There was no sustained therapeutic benefit as measured by increased production of endogenous insulin, or of C-peptide, or by a lower requirement for exogenous insulin. Further trials with interferon treatment should be undertaken only if evidence of active viral infection (culture, antigen detection) can be associated with insulin dependent diabetes onset and these markers followed during treatment.

Citations

Jul 1, 1985·Acta diabetologica latina·M MorsianiL Bottoni
Feb 10, 1983·The New England Journal of Medicine·A A Rossini
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Oct 1, 1987·Diabetes/metabolism Reviews·J S Skyler
Nov 1, 1985·Diabetic Medicine : a Journal of the British Diabetic Association·J NerupT Mandrup-Poulsen
Jan 22, 2003·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·William E Winter, Desmond Schatz
May 1, 1987·Postgraduate Medicine·P G Colman, G S Eisenbarth

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