PMID: 8611399Apr 1, 1996Paper

Human liver cancer cells and endothelial cells incorporate iodised oil

British Journal of Cancer
S BhattacharyaK E Hobbs

Abstract

Iodised oil (lipiodol) administered via the hepatic artery localises selectively in primary liver cell cancers (hepatocellular carcinomas or HCCs) for prolonged periods and has been used as a vehicle for cytotoxic agents. Despite clinical use, the mechanism of lipiodol retention by tumours has remained unclear, embolisation of oil droplets in the tumour vasculature being the prevailing hypothesis. We have investigated the role of tumour and endothelial cells in lipiodol retention. Human liver tumour (Hep G2) cells and human umbilical vein endothelial cells in culture were exposed to lipiodol. Light microscopy using selective silver impregnation stains and transmission electron microscopy revealed lipiodol incorporation by both cell types, probably by pinocytosis. This was not associated with cellular injury in terms of cell lysis, cell replication or radio-labelled leucine uptake. Histological analysis of 24 HCCs either surgically resected or discovered incidentally at liver transplantation (with prior arterial injection of lipiodol) revealed vesicles of lipiodol in the cytoplasm of tumour cells and endothelial cells lining tumour vessels. Thus, lipiodol is likely to deliver cytotoxic agents directly into tumour cells and endot...Continue Reading

Citations

Jun 17, 2008·European Radiology·Thomas J VoglSebastian Lindemayr
Jul 21, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Bieke Lambert, Christophe Van de Wiele
Apr 21, 2010·The Cancer Journal·Eleni Liapi, Jean-Francois H Geschwind
May 20, 2015·Nature Reviews. Clinical Oncology·Ali HabibRiad Salem
May 24, 2011·Radiology·Robert J LewandowskiRiad Salem
Mar 22, 2016·Hepatic Oncology·Fabrizio ChegaiLorenzo Mannelli
Jun 1, 2014·Hepatic Oncology·Ryan M HickeyRiad Salem
Jul 27, 2001·Journal of Surgical Oncology·P MorozB N Gray
Nov 12, 2010·Cardiovascular and Interventional Radiology·Eleni Liapi, Jean-Francois H Geschwind
Apr 21, 2010·Annals of Surgical Oncology·Eleni Liapi, Jean-Francois H Geschwind
May 16, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Laura MarelliAndrew K Burroughs
Feb 25, 2014·Molecular Pharmaceutics·Ilse R DubbelboerHans Lennernäs
Jan 5, 2006·Journal of Translational Medicine·Thomas E IchimEugenia K Oleinik

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