Human Liver Fatty Acid Binding Protein-1 T94A Variant, Nonalcohol Fatty Liver Disease, and Hepatic Endocannabinoid System

Lipids
Gregory G MartinFriedhelm Schroeder

Abstract

Hepatic endocannabinoids (EC) and their major binding/"chaperone" protein (i.e., liver fatty acid binding protein-1 [FABP1]) are associated with development of nonalcoholic fatty liver (NAFLD) in animal models and humans. Since expression of the highly prevalent human FABP1 T94A variant induces serum lipid accumulation, it is important to determine its impact on hepatic lipid accumulation and the EC system. This issue was addressed in livers from human subjects expressing only wild-type (WT) FABP1 T94T (TT genotype) or T94A variant (TC or CC genotype). WT FABP1 males had lower total lipids (both neutral cholesteryl esters, triacylglycerols) and phospholipids than females. WT FABP1 males' lower lipids correlated with lower levels of the N-acylethanolamide DHEA and 2-monoacylglycerols (2-MAG) (2-OG, 2-PG). T94A expression in males increased the hepatic total lipids (triacylglycerol, cholesteryl ester), which is consistent with their higher level of CB1-potentiating 2-OG and lower antagonistic EPEA. In contrast, in females, T94A expression did not alter the total lipids, neutral lipids, or phospholipids, which is attributable to the higher cannabinoid receptor-1 (CB1) agonist arachidonoylethanolamide (AEA) and its CB1-potentiator ...Continue Reading

References

Jan 1, 1993·American Journal of Hematology·S Piomelli, C Seaman
May 1, 1997·Archives of Biochemistry and Biophysics·C A JollyF Schroeder
Sep 4, 1997·Nature·R MechoulamZ Vogel
Jun 19, 1998·Chemistry and Physics of Lipids·F SchroederA Frolov
Oct 10, 2001·Progress in Lipid Research·A M GallegosF Schroeder
Jan 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Lei WangGeorge Kunos
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
May 3, 2005·The Journal of Clinical Investigation·Aron H Lichtman, Benjamin F Cravatt
May 9, 2007·Molecular Genetics and Metabolism·Eva FisherFrank Döring
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Oct 20, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·January N BaumgardnerMartin J J Ronis
May 10, 2008·Biochemistry·Gregory G MartinFriedhelm Schroeder
Mar 18, 2009·Journal of Lipid Research·Heather A HostetlerFriedhelm Schroeder
Mar 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Martin KaczochaDale G Deutsch
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael CharltonMichael Sarr
Jun 2, 2009·Chemistry & Biology·Sergio OddiMauro Maccarrone
Jan 19, 2010·Annual Review of Pathology·Dina G TiniakosElizabeth M Brunt
Mar 6, 2010·The AAPS Journal·Vishnudutt PurohitDavid Shurtleff
Mar 23, 2010·Drug Discovery Today·Giulio G Muccioli
May 14, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Wenying JianHao Wang
Jul 22, 2010·Annual Review of Nutrition·Mauro MaccarroneLuciana Avigliano
Aug 17, 2010·Gastroenterology·Naga ChalasaniUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jan 11, 2011·Biochimica Et Biophysica Acta·Ingrid C GaemersWouter H Lamers
Jan 22, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph TamGeorge Kunos
Feb 4, 2011·Diabetes Research and Clinical Practice·Liming BuMarino De Leon
May 5, 2011·Molecular and Cellular Biochemistry·Heather A HostetlerFriedhelm Schroeder
Nov 8, 2011·Biochimica Et Biophysica Acta·Anne TailleuxBart Staels
May 2, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M GraffI B Borecki
Sep 18, 2012·Current Drug Metabolism·Aurore Vluggens, Janardan K Reddy
Sep 22, 2012·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Simon Eringsmark Regnell
Dec 15, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anca D PetrescuFriedhelm Schroeder
Dec 26, 2012·Diabetes & Metabolism·K GarianiF R Jornayvaz

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