Human Lung Mononuclear Phagocytes in Health and Disease

Frontiers in Immunology
Faezzah BaharomAnna Smed-Sörensen

Abstract

The lungs are vulnerable to attack by respiratory insults such as toxins, allergens, and pathogens, given their continuous exposure to the air we breathe. Our immune system has evolved to provide protection against an array of potential threats without causing collateral damage to the lung tissue. In order to swiftly detect invading pathogens, monocytes, macrophages, and dendritic cells (DCs)-together termed mononuclear phagocytes (MNPs)-line the respiratory tract with the key task of surveying the lung microenvironment in order to discriminate between harmless and harmful antigens and initiate immune responses when necessary. Each cell type excels at specific tasks: monocytes produce large amounts of cytokines, macrophages are highly phagocytic, whereas DCs excel at activating naïve T cells. Extensive studies in murine models have established a division of labor between the different populations of MNPs at steady state and during infection or inflammation. However, a translation of important findings in mice is only beginning to be explored in humans, given the challenge of working with rare cells in inaccessible human tissues. Important progress has been made in recent years on the phenotype and function of human lung MNPs. I...Continue Reading

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Citations

Dec 13, 2017·Frontiers in Immunology·Karen BohmwaldAlexis M Kalergis
Feb 16, 2019·Immunology and Cell Biology·Franz PutturClare M Lloyd
Feb 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sindhu VangetiAnna Smed-Sörensen
Jun 6, 2018·The Journal of Infectious Diseases·Monica SassiJoseph A Kovacs
Nov 13, 2019·Immunology·Elza EvrenTim Willinger
Sep 20, 2020·Scientific Reports·Casper J E WahlundSusanne Gabrielsson
Apr 4, 2021·International Journal of Molecular Sciences·Bijean D FordRabindra Tirouvanziam
Aug 10, 2021·Frontiers in Immunology·Rainer KnollJonas Schulte-Schrepping
Aug 29, 2021·Pathogens·Lisa J M SlimmenWendy W J Unger
Oct 19, 2020·Pediatric Research·Olachi J Mezu-Ndubuisi, Akhil Maheshwari

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Methods Mentioned

BETA
bronchoalveolar
biopsies
surgical resections
lavages
flow cytometry
bronchoalveolar lavage
electron microscopy
lavage

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