PMID: 9444445Jan 28, 1998Paper

Human lymphoblastoid interferon treatment for patients with hepatitis C virus-related cirrhosis

Clinical Therapeutics
N FurusyoS Kashiwagi

Abstract

To evaluate the efficacy and safety of human lymphoblastoid interferon treatment (interferon alfa) for patients with compensated cirrhosis caused by hepatitis C virus (HCV) infection, we randomly assigned 82 cirrhotic patients with chronic HCV infection (44 men, 38 women; mean age, 58.6 years) to two groups: 41 patients were treated with interferon alfa (480 million U over 6 months), and the other patients received no drug treatment. HCV RNA genotypes were determined by polymerase chain reaction (PCR) testing using type-specific primers. HCV RNA levels were measured by competitive PCR testing. No untreated patients eliminated HCV RNA from the serum or had a decrease in the level of alanine aminotransferase to normal during the observation period. Of the 34 patients who completed interferon alfa treatment, 6 (17.6%) who were considered complete responders eliminated HCV RNA from the serum by the end of treatment and sustained this elimination throughout a 6-month follow-up period. Complete responders constituted 6 (46.2%) of 13 patients with HCV RNA levels < or = 10(5) copies/50 microL, but none of the 21 patients with levels > 10(5) copies/50 microL were complete responders. Two (7.1%) of 28 patients with genotype 1b infection ...Continue Reading

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Citations

Apr 25, 2000·Journal of Clinical Gastroenterology·C ZavagliaG Pinzello
Sep 17, 2010·World Journal of Gastroenterology : WJG·Mosaburo KainumaUNKNOWN Kyushu University Liver Disease Study Group
Dec 24, 2003·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kenichiro KashiwagiJun Hayashi
Oct 9, 2013·Alimentary Pharmacology & Therapeutics·E OgawaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
Nov 23, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mosaburo KainumaUNKNOWN Kyushu University Liver Disease Study (KULDS) Group
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Mar 8, 2006·World Journal of Gastroenterology : WJG·Norihiro FurusyoUNKNOWN Kyushu University Liver Disease Study Group

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