Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm.

Journal of Clinical Laboratory Analysis
Yao-Yuan HsiehFuu-Jen Tsai

Abstract

HLA-B associated transcript (BAT) 2, 3, and 5 polymorphisms and haplotypes are associated with Kawasaki disease (KD) and coronary artery aneurysm (CAA) formations. KD, an acute vasculitis with unknown etiology, involves a complex interaction of immuno-inflammatory process, cytokines activation, and genetic factors. We aimed to investigate if genetic variants of human lymphocyte antigen (HLA)-BAT2, 3, and 5 (BAT2, 3, and 5) could be used as markers of susceptibility in KD and CAA. Individuals were divided into three groups: (1) normal controls; (2) KD with CAA; and (3) KD without CAA. Polymorphisms for BAT2 (-8671, 16483), BAT3 (8854, 2-24), and BAT5 (22655, 9569) were genotyped by PCR system with TaqMan allelic discrimination assay. Genotype/allelic frequencies and haplotypes (BAT2(-8671)-BAT2(16483)-BAT3(8854)-BAT3(2-24)-BAT5(22655)-BAT5(9569)) in each group were compared. Genotype distribution and allele frequency of BAT2 -8671, BAT3 8854, and BAT5 22655, 9569 polymorphisms in each group were significantly different. BAT2 -8671*G, BAT3 8854*C, BAT5 22655*C, and 9569*A-related genotypes and alleles are correlated with the developments of KD and CAA. BAT haplotypes of ATTGTG and ATCATG are associated with higher susceptibilitie...Continue Reading

References

Nov 1, 1992·The Journal of Pediatrics·T AkagiR M Freedom
Aug 24, 1999·Pediatrics International : Official Journal of the Japan Pediatric Society·S KamizonoK Itoh
Nov 24, 1999·Molecular Medicine Today·P Y Kwok, Z Gu
Jul 19, 2000·Experimental and Clinical Immunogenetics·Y HuangJ G Chang
May 15, 2002·The Journal of Pediatrics·Shirley M L TseRae S M Yeung
Apr 8, 2004·The Journal of Pediatrics·Hiromi MutaToyojiro Matsuishi
Apr 13, 2004·Arthritis and Rheumatism·Alfonso MartinezBenjamin Fernandez-Gutierrez
Aug 11, 2004·Lancet·Jane C Burns, Mary P Glodé
Mar 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Shuen-Iu HungYuan-Tsong Chen
Jun 23, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·O MigitaT Arinami
Apr 19, 2006·The Journal of Infectious Diseases·Rajendranath RamasawmyAnna Carla Goldberg
May 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silvio DaneseClaudio Fiocchi
Aug 22, 2008·Journal of Neuroinflammation·Anastazija GnjecRalph N Martins
Oct 15, 2008·PloS One·Venkateswara Rao SimhadriElke Pogge von Strandmann
Nov 4, 2008·Human Immunology·Jae-Jung KimJong-Keuk Lee
Apr 25, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elisabetta RicciAnita De Rossi

❮ Previous
Next ❯

Citations

Jan 11, 2012·Current Rheumatology Reports·Ezgi Deniz Batu, Seza Ozen
Dec 7, 2013·Cellular and Molecular Life Sciences : CMLS·Janina Binici, Joachim Koch
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jee-Young MockWilliam Melvon Clemons
Feb 19, 2013·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jin-Gu Lee, Yihong Ye
Jan 1, 2013·Diagnostics·Sunil J GhelaniChristopher F Spurney
Jan 18, 2017·Pediatrics International : Official Journal of the Japan Pediatric Society·Hong-Je ChoJi-Eun Ban
Sep 29, 2020·Frontiers in Pediatrics·Danfeng ZhangJie Tian
Jul 3, 2021·Journal of Medicinal Chemistry·Giulia BononiCarlotta Granchi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.