PMID: 6970726Aug 1, 1980Paper

Human lymphocyte/human erythrocyte rosettes. I. Blood "H" rosettes are high-affinity E-rosetting-forming T lymphocytes occurring in high frequency

International Journal of Cancer. Journal International Du Cancer
L A GallingerM G Baines

Abstract

Human lymphocytes will rosette with human red blood cells under certain conditions (H rosettes). The work presented in this paper documents the following: (1) a reproducible short-term assay for the detection of H rosettes in proportions similar to those reported recently in the literature (25-30%); (2) technical improvements on the basic assay system demonstrating that, in fact, 40-65% of human lymphocytes form H rosettes; (3) the fact that, in normal donors, auto and allo H rosettes are formed by identical lymphocyte subpopulations; (4) that H rosettes are formed independently of the ABH, Rh and Thomsen-Freidenreich (TF) red-cell antigens on the indicator red cells; and (5) that H rosette-forming cells consist almost entirely of T lymphocytes having high-affinity receptors for sheep erythrocytes. The large difference in size between sheep and human RBC made it possible to do double rosette assays in which high- and low-affinity E-rosette-forming T cells could be visualized on the same slide. As with T lymphocytes in general, a large proportion of HRFC was found to have Fc-IgM receptors while a smaller proportion has Fc-IgG receptors. Studies done on a small group of leukemic patients supported the T-cell nature of the H roset...Continue Reading

References

Sep 1, 1975·Clinical Immunology and Immunopathology·S HorowitzR Hong
Mar 15, 1978·International Journal of Cancer. Journal International Du Cancer·H F ProssM G Baines
Jul 1, 1979·Cellular Immunology·S GuptaR A Good
Feb 1, 1977·Cellular Immunology·C CarnaudJ F Bach
Jan 1, 1977·Journal of Immunological Methods·M LambermontA Govaerts
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·H F Pross, M G Baines
Jan 1, 1975·International Archives of Allergy and Applied Immunology·S Gupta, M H Grieco
Jan 1, 1975·European Journal of Immunology·M FerrariniM L Durante
Aug 1, 1975·European Journal of Immunology·L MorettaM C Mingari
Mar 1, 1975·Clinical Immunology and Immunopathology·J Kaplan
Aug 3, 1974·Lancet·J Charreire, J F Bach
Aug 31, 1974·Lancet·A E DewarC Wilson
Jul 1, 1973·Clinical Immunology and Immunopathology·Z BentwichH G Kunkel
Jul 1, 1974·Journal of Immunological Methods·M E Kaplan, C Clark
Apr 1, 1973·Clinical Immunology and Immunopathology·J WybranH H Fudenberg
Aug 29, 1970·Nature·H S MicklemN Anderson
Jan 1, 1970·International Archives of Allergy and Applied Immunology·R R CoombsB Lindgren
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation·C E Mogensen
Oct 23, 1965·Nature·G J Johnson, P S Russell

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Citations

Dec 1, 1984·Cellular Immunology·I StefasB Serrou
Mar 30, 1984·Journal of Immunological Methods·H F Pross, J A Maroun
Nov 1, 1981·Cellular Immunology·M RuchetonB Serrou
Sep 15, 1984·International Journal of Cancer. Journal International Du Cancer·H F ProssD R MacGillis
Jan 1, 1993·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T KhavkinD Testa
May 1, 1985·American Journal of Reproductive Immunology and Microbiology : AJRIM·H ProssJ Werkmeister

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