PMID: 9553652Apr 29, 1998Paper

Human lymphocytes obtained from decidual tissue express killer activatory receptors as well as killer inhibitory receptors: analysis using a single strand conformation polymorphism method

American Journal of Reproductive Immunology : AJRI
A MikiT Juji

Abstract

The objective was to clarify whether lymphocytes in decidual tissue express only killer inhibitory receptors (KIRs) or both KIRs and killer activatory receptors (KARs). A polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) analysis method, using cDNA as a template, was applied to detect as many natural killer receptors (NKRs) expressed on natural killer (NK) cells as possible and to distinguish between KIRs and KARs. Using this method, we analyzed NKRs on lymphocytes in decidual tissue and maternal peripheral blood mononuclear cells (PBMCs) (n = 10) from the same individuals. More than 20 SSCP bands were detected for NKRs on both the lymphocytes in decidual tissue and the maternal PBMCs. The SSCP band patterns were different for each individual. KARs mRNA was detected in lymphocytes in decidual tissue according to the SSCP analysis results. Lymphocytes in decidual tissue express not only KIRs but also KARs; this finding suggests their roles in placentation and the maintenance of pregnancy.

References

Dec 1, 1991·Immunology Today·A King, Y W Loke
Jun 1, 1990·American Journal of Obstetrics and Gynecology·K Benirschke
Jul 1, 1990·American Journal of Reproductive Immunology : AJRI·S Ellis
Apr 13, 1990·Science·S KovatsR DeMars
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M OritaT Sekiya
Nov 16, 1995·Nature·J E Gumperz, P Parham
Aug 1, 1994·The Journal of Experimental Medicine·V LitwinL L Lanier
May 1, 1994·Cellular Immunology·G ChumbleyY W Loke
Jan 1, 1996·Immunogenetics·C DöhringM Colonna
Feb 1, 1996·Immunology Today·L L Lanier, J H Phillips
Feb 3, 1997·The Journal of Experimental Medicine·C MünzH G Rammensee
Apr 1, 1997·European Journal of Immunology·S VermaY W Loke
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·N Rouas-FreissE D Carosella

❮ Previous
Next ❯

Citations

Aug 5, 2000·Journal of Reproductive Immunology·S Saito
Apr 2, 1999·Immunology and Cell Biology·H S Warren, M J Smyth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.