Abstract
This study was carried out to determine the take rate of malignant lymphomas transplanted subcutaneously in nude mice. Lymphoid tissue from patients with a variety of lymphoproliferative and lymphomatous disorders was employed, but only four (8.3% of total) non-Hodgkin's lymphomas of various types grew in the nude mice. These transplants were from patients with lymphoplasmacytic, lymphoblastic, immunoblastic and centroblastic lymphomas; two of them were serially transferred. High grade malignant lymphomas seem easier to transplant than low grade ones. In each case, the tumor growing in nude mice was similar to the patient's tumor. In one case, metastases were found in mesenteric lymph nodes and lung. Electron microscopic study showed that neoplastic cells were associated with peculiar dark cells the nature of which is discussed. Furthermore, in two transplanted lymphomas, neoplastic cells contained C type virus particles, indicating contamination by the murine xenotropic type C virus.
References
Jun 15, 1979·International Journal of Cancer. Journal International Du Cancer·M SchaadtV Diehl
Jul 1, 1975·Journal of the National Cancer Institute·T S TralkaC T Hansen
May 1, 1976·Cancer·A L EpsteinH S Kaplan
Jan 1, 1979·British Journal of Cancer·H WunderliD F Paulson
Feb 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·P C Zamecnik, J C Long
May 15, 1977·Experientia·U B SinghS K Ranjhan
Dec 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D R MorganD E Onions
Oct 1, 1978·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P R MerlettiA Goldin
Oct 5, 1974·Lancet·C R Taylor
Dec 14, 1973·Science·J A Levy
Jan 15, 1973·International Journal of Cancer. Journal International Du Cancer·C O PovlsenF Wiener
Jan 1, 1969·Acta Pathologica Et Microbiologica Scandinavica·J Rygaard, C O Povlsen
Jan 27, 1968·Nature·E M Pantelouris
Dec 1, 1966·Genetical Research·S P Flanagan