Human macrophage metalloelastase worsens the prognosis of pancreatic cancer

Annals of Surgery
Peter BalazMarkus W Büchler

Abstract

To evaluate the role of human macrophage metalloelastase (HME) in pancreatic cancer. HME, a member of the human matrix metalloproteinase family, possesses elastolytic activity and is critical for the degradation of extracellular matrix proteins. Inasmuch as tumor invasion and metastasis formation require lysis of extracellular matrix, HME plays a critical role in both processes. HME expression was analyzed by Northern blot analysis, reverse transcriptase-polymerase chain reaction, Western blot analysis, and immunohistochemistry in 39 pancreatic cancer tissues and 13 normal controls. The molecular data were related to clinicopathologic parameters and patient survival. In human pancreatic cancer, overexpression of HME mRNA was present in 25 of 39 pancreatic cancer tissues (64%) and in five pancreatic cancer cell lines. In contrast, low levels of HME mRNA expression were present in 13 normal pancreatic tissues samples. By Western blot analysis, high levels of HME were found in pancreatic cancer tissues and in the pancreatic cancer cell lines compared with the normal controls. Fifty-six percent of the cancer samples exhibited HME immunoreactivity in the cancer cells, and 63% in the stromal cells. Analysis of the survival data revea...Continue Reading

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Citations

Feb 4, 2010·Digestive Diseases and Sciences·Peng ChengYan Jie Zhang
May 24, 2006·The Journal of Pathology·R RustA van den Berg
Jan 3, 2013·Journal of Surgical Oncology·Jianyong ZhengQingchuan Zhao
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Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Yan LiDong-Jie Wang

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