PMID: 2166075Jun 1, 1990

Human malignant melanoma cell line (HMV-II) for isolation of influenza C and parainfluenza viruses

Journal of Clinical Microbiology
H MoriuchiY Numazaki


HMV-II, a human malignant melanoma cell line, was compared with other cell lines (MDCK, Vero, and LLC-MK2) and primary cultures of monkey kidney (PMK) cells for the isolation and quantification of influenza and parainfluenza viruses. HMV-II cells were superior to MDCK and LLC-MK2 cells in quantification of the influenza C virus and were used successfully in the isolation of the virus from clinical specimens. The HMV-II cell line was also more sensitive for isolating parainfluenza viruses from clinical specimens than were Vero and PMK cells; there was, however, no significant difference in the quantification of the viruses among these cultures. As far as influenza A and B viruses were concerned, the HMV-II cell line was significantly less sensitive than MDCK cells, and no virus was isolated from clinical specimens with HMV-II cells. Thus, HMV-II cells are useful for the isolation of influenza C and parainfluenza viruses as an alternative to embryonated hen's eggs and PMK cells.


Jun 1, 1997·Annals of Tropical Paediatrics·Katsumi MizutaY Numazaki
Mar 1, 2013·Influenza and Other Respiratory Viruses·Kanti PabbarajuKevin Fonseca
Apr 15, 2003·Clinical Microbiology Reviews·Kelly J Henrickson

Related Concepts

Chick Embryo
Cytopathogenic Effect, Viral
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Orthomyxoviridae Infections
Influenza C Virus
Tumor Cells, Cultured

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