PMID: 6979363Mar 1, 1982Paper

Human marrow stromal cells in culture: changes induced by T-lymphocytes

Blut
M Y GordonD Grennan

Abstract

Suspension cultures of human bone marrow mononuclear cells form colonies of fibroblastoid cells which expand to form confluent monolayers. These fibroblastoid cells are thought to represent elements of the bone marrow stroma. Fibroblastoid cells failed to proliferate when the cultures were initiated and maintained in the presence of 50% (v/v) of medium conditioned by phytohaemagglutinin (PHA)-stimulated blood mononuclear cells or supernatant media from one-way mixed lymphocyte reactions (MLR). Under these conditions, the cultures contained a pleomorphic population of macrophage-like cells. Some of the characteristics of the fibroblastoid and macrophage-like cells have been compared and a separate origin of the two cell types has been demonstrated. Further experiments indicated that T lymphocytes were the source of the factor(s) in the conditioned media which was responsible for the growth of the macrophage-like cells at the expense of the fibroblastoid cells and suggested that activation of the T cells was necessary for them to exert their effect. The results support the idea that T lymphocytes can influence the haemopoietic microenvironment of the bone marrow.

References

Mar 27, 1976·Lancet·J AscensãoR Good
Jan 1, 1979·American Journal of Hematology·B Löwenberg, H M De Zeeuw
Jan 1, 1979·Haematology and Blood Transfusion·H L HaakJ L Waayer
Oct 1, 1979·The Journal of Experimental Medicine·H Westen, D F Bainton
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W A KaganR A Good
Mar 1, 1975·The Journal of Clinical Investigation·F W Ruscetti, P A Chervenick
Nov 1, 1967·The Journal of Experimental Medicine·J L Curry, J J Trentin
May 1, 1981·British Journal of Haematology·M A McMillen, R L Simmons

❮ Previous
Next ❯

Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·I FohlmeisterR Fischer
Nov 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V S AstakhovaL Iu Poludnenko
Jul 1, 1985·Biulleten' eksperimental'noĭ biologii i meditsiny·A V Sidorenko
Feb 1, 1994·British Journal of Haematology·M Y Gordon
Jan 1, 1989·Annals of the New York Academy of Sciences·B A Naughton, G K Naughton
Dec 1, 1983·International Journal of Cell Cloning·M Y GordonE C Gordon-Smith
Mar 1, 1983·British Journal of Haematology·M Y Gordon, E C Gordon-Smith
Jan 1, 1987·Journal of Cellular Physiology·M Y GordonM F Greaves

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.