PMID: 9524071Apr 2, 1998Paper

Human matrix metalloprotease activation by insults of bacterial infection involving proteases and free radicals

Biological Chemistry
H MaedaT Akaike

Abstract

We found that human matrix metalloproteases (MMPs) may be processed from their proenzyme forms (proMMP) to their active forms by two new and unique mechanisms: Firstly, by bacterial proteases such as Pseudomonas elastase and Vibrio cholerae protease, which cleave off the N-terminal autoinhibitory domain (so-called cysteine switch) from proMMPs. The second mechanism depends on free radical generation by activated polymorphonuclear leukocytes (PMNs). In this case, peroxynitrite (ONOO-) or nitrogen dioxide radical (.NO2), the reaction products of either superoxide (O2.-) or molecular oxygen (O2) and nitric oxide (.NO), are the key reactants. Both O2.- and .NO are generated by activated macrophages and PMNs as a result of immunologic responses involving various proinflammatory cytokines. .NO2 or ONOO- seems to interact with a single cysteine residue in the propeptide autoinhibitory domain, or so-called cysteine switch of proMMPs, thus transforming proMMPs into their active conformation. Furthermore, reactive oxygen species are known to inactivate the alpha1-protease inhibitor (alpha1-PI), a potent neutrophil elastase inhibitor in plasma. In addition, we found that such radicals activate MMPs which degrade and inactivate alpha1-PI b...Continue Reading

References

May 1, 1992·Chemical Research in Toxicology·J J Moreno, W A Pryor
Sep 28, 1990·Biochemical and Biophysical Research Communications·H SaariT Sorsa
Oct 1, 1995·Trends in Microbiology·J TravisH Maeda
Jan 1, 1996·Microbiology and Immunology·H Maeda
Feb 28, 1997·The Journal of Biological Chemistry·T OkamotoH Maeda

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Citations

Sep 10, 2002·Bulletin of Mathematical Biology·Jonathan A SherrattNicholas J Savill
Nov 27, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sabine KochChristoph V Suschek
Oct 28, 2010·Cancer Immunology, Immunotherapy : CII·Salomé González-ReyesFrancisco J Vizoso
Jul 20, 2010·Amino Acids·T Klein, R Bischoff
Aug 15, 2001·European Journal of Pharmacology·S KastenbauerH W Pfister
Nov 8, 2001·European Journal of Pharmacology·G FolkertsF P Nijkamp
Dec 22, 1999·Immunopharmacology·H MaedaT Akaike
Mar 10, 2000·Biochimica Et Biophysica Acta·J Travis, J Potempa
Jan 22, 2004·FEMS Microbiology Letters·Mohammed H RashidDavid K R Karaolis
Mar 10, 2001·Veterinary Microbiology·B A MungallC C Pollitt
May 26, 1999·Infectious Disease Clinics of North America·S Sriskandan, J Cohen
Feb 22, 2001·Free Radical Biology & Medicine·J FuchsM Podda
Apr 18, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G ZieglerD Fisher
Jul 10, 2003·Lancet Neurology·Kenneth J Smith, Hans Lassmann
Mar 18, 2003·International Immunopharmacology·Hiroshi MaedaYasunori Kitamoto
Jun 5, 2013·Immunology and Cell Biology·Filip PetkovićDjordje Miljković
Oct 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Lisa A RidnourDavid A Wink
Jun 17, 2011·Antioxidants & Redox Signaling·Martha LappasAlicia Jawerbaum
Feb 13, 2001·The British Journal of Ophthalmology·V A SmithD L Easty
Jan 9, 2004·Archives of Disease in Childhood. Fetal and Neonatal Edition·A E CurleyH L Halliday
Feb 5, 2005·Médecine sciences : M/S·David Marsolais, Jérome Frenette
Jul 16, 2005·Experimental Lung Research·Subhadeep Chakrabarti, Kamala D Patel
Sep 4, 2010·Critical Reviews in Biochemistry and Molecular Biology·Bénédicte Cauwe, Ghislain Opdenakker
Aug 8, 2002·The Journal of Investigative Dermatology·Steven J WallGillian Murphy
Jul 18, 2015·Environmental Research·Ryan ClantonGamal Akabani
Oct 18, 2014·Seminars in Ophthalmology·Marie-Claude Robert, Claes H Dohlman
Jan 12, 2002·Journal of Theoretical Biology·Nicholas J SavillJonathan A Sherratt
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Shaila J MerchantSandra T Davidge
Jul 7, 2007·Canadian Journal of Physiology and Pharmacology·Hernando LeónRichard Schulz
Feb 26, 2004·Journal of the Society for Gynecologic Investigation·S J MerchantL J Guilbert
May 3, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G ToncevG Samardzic
May 21, 2015·World Journal of Experimental Medicine·Andrea PredonzaniBarbara Molon
Jun 20, 2007·Oral Diseases·D N Della RicciaM G Cifone
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K D Kröncke
Apr 30, 2017·Experimental and Therapeutic Medicine·Ofer PragerYaffa Mizrachi Nebenzahl
Apr 14, 2016·International Ophthalmology·Riccardo ScottoCarlo E Traverso
Feb 16, 1999·Brain Pathology·K J SmithP A Felts
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·P G PhillipsW L Milonovich

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