Human-Mediated Introgression of Haplotypes in a Modern Dairy Cattle Breed

Genetics
Qianqian ZhangBernt Guldbrandtsen

Abstract

Domestic animals can serve as model systems of adaptive introgression and their genomic signatures. In part, their usefulness as model systems is due to their well-known histories. Different breeding strategies such as introgression and artificial selection have generated numerous desirable phenotypes and superior performance in domestic animals. The modern Danish Red Dairy Cattle is studied as an example of an introgressed population. It originates from crossing the traditional Danish Red Dairy Cattle with the Holstein and Brown Swiss breeds, both known for high milk production. This crossing happened, among other things due to changes in the production system, to raise milk production and overall performance. The genomes of modern Danish Red Dairy Cattle are heavily influenced by regions introgressed from the Holstein and Brown Swiss breeds and under subsequent selection in the admixed population. The introgressed proportion of the genome was found to be highly variable across the genome. Haplotypes introgressed from Holstein and Brown Swiss contained or overlapped known genes affecting milk production, as well as protein and fat content (CD14, ZNF215, BCL2L12, and THRSP for Holstein origin and ITPR2, BCAT1, LAP3, and MED28 f...Continue Reading

References

Jan 11, 2000·Nucleic Acids Research·S T SherryK Sirotkin
Feb 24, 2001·The Journal of Heredity·J KantanenS Adalsteinsson
Apr 2, 2003·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A M AlluwaimiJ S Cullor
Apr 28, 2009·Genome Biology·Aleksey V ZiminSteven L Salzberg
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Aug 4, 2009·Genome Research·David H AlexanderKenneth Lange
Dec 1, 2006·PLoS Biology·Emma Hill
Dec 21, 2010·American Journal of Human Genetics·Jian YangPeter M Visscher
Jul 26, 2011·Database : the Journal of Biological Databases and Curation·Rhoda J KinsellaPaul Flicek
Dec 24, 2011·Genetics and Molecular Research : GMR·M C BaezaM C Miquel
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·J W M MerksE F Knol
Nov 21, 2012·PLoS Genetics·Joseph K Pickrell, Jonathan K Pritchard
Jan 7, 2014·Genetics·Yongtao Guan
Jan 31, 2014·BMC Genetics·Mohammed K Abo-IsmailStephen P Miller
Mar 13, 2014·Animal Reproduction Science·D M HeringS Kaminski
Jun 3, 2014·Genetics, Selection, Evolution : GSE·Zi-Qing WengDorian J Garrick
Feb 28, 2015·GigaScience·Christopher C ChangJames J Lee
May 4, 2015·BMC Genetics·Goutam SahanaMogens S Lund

❮ Previous
Next ❯

Citations

Jul 28, 2020·Animal Genetics·K ZhangJ Liu
Mar 29, 2020·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·Salvatore MastrangeloMartino Cassandro
Nov 22, 2018·Genetics, Selection, Evolution : GSE·Qianqian ZhangMario P L Calus
Oct 14, 2019·Journal of Dairy Science·Md Mesbah-UddinGoutam Sahana
Mar 8, 2021·Genetics, Selection, Evolution : GSE·Christin SchmidtmannGeorg Thaller

❮ Previous
Next ❯

Datasets Mentioned

BETA
SRR1293227

Methods Mentioned

BETA
PCA

Software Mentioned

Beagle
FlexMix
samtools
Genepop
Admixture
threepop
Beagle fastIBD
Genome Analysis Toolkit
BioMart
UnifiedGenotyper

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.