Human mesenchymal stem cells exploit the immune response mediating chemokines to impact the phenotype of glioblastoma

Cell Transplantation
Helena MotalnTamara T Lah

Abstract

In contrast to the application of human mesenchymal stem cells (hMSCs) in regenerative medicine, only a limited number of studies are addressing their use in anticancer therapy. As the latter may represent a new hope to improve the survival of patients with glioblastoma multiformae (GBM), the most common and malignant form of the brain tumors, we aimed to investigate the interactions of hMSCs and GBM cells under in vitro conditions. Four hMSC clones and three different GBM cell lines were used to study their mutual paracrine interactions in cocultures compared to their monocultures, where cells were grown under the same experimental conditions. The effects on cell growth, proliferation, and invasion in Matrigel were quantified. Further, bioinformatics tools were used to relate these results to the data obtained from cytokine macroarrays and cDNA microarrays that revealed proteins and genes significantly involved in cellular cross-talk. We showed that hMSCs are responsible for the impairment of GBM cell invasion and growth, possibly via induction of their senescence. On the other hand, GBM cells inversely affected some of these characteristics in hMSCs. We found CCL2/MCP-1 to be the most significantly regulated chemokine during ...Continue Reading

References

Jun 5, 1999·Cellular and Molecular Life Sciences : CMLS·G J MaestroniP Galli
Apr 13, 2002·Journal of Neuro-oncology·Tammy KielianWilliam F Hickey
May 20, 2003·Journal of Neurochemistry·E A EugeninJ W Berman
Jul 2, 2003·Nature Reviews. Cancer·Jasti S Rao
Sep 25, 2003·Acta neurochirurgica·N LevicarR K Nutall
Jun 28, 2005·Journal of Neuropathology and Experimental Neurology·Hiroko Ohgaki, Paul Kleihues
Aug 13, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Kalevi J Pulkkanen, Seppo Yla-Herttuala
Sep 15, 2005·Cancer Letters·Eriko MichishitaIzumi Horikawa
Oct 11, 2005·Experimental and Molecular Pathology·Wei ZhuYongchang Chen
Mar 1, 2006·Expert Opinion on Biological Therapy·Tamara T LahCornelis J F Van Noorden
Apr 26, 2006·The Journal of Experimental Medicine·Aarif Y KhakooToren Finkel
Aug 31, 2006·Methods in Enzymology·Alexander I SaeedJohn Quackenbush
Nov 14, 2006·Bioinformatics·S Falcon, R Gentleman
Mar 24, 2007·American Journal of Respiratory Cell and Molecular Biology·Xiangde LiuStephen I Rennard
May 25, 2007·Cancer Immunology, Immunotherapy : CII·Justin T JordanAmy B Heimberger
Jun 16, 2007·Journal of Neuro-oncology·Tobias BirnbaumAndreas Straube
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Aug 19, 2007·Journal of Neuro-oncology·Yu LiangNalin Gupta
Oct 5, 2007·Nature·Antoine E KarnoubRobert A Weinberg
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Feb 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Seth B CoffeltAline B Scandurro
Jun 16, 2009·Cell Transplantation·Der-Yang ChoShih-Ping Liu
Nov 3, 2009·Neoplasia : an International Journal for Oncology Research·Kosuke MizutaniKenneth J Pienta
Dec 3, 2009·The Journal of Cell Biology·Peter Friedl, Katarina Wolf
Mar 20, 2010·Cancer·Helena MotalnTamara T Lah
Mar 27, 2010·International Journal of Colorectal Disease·Paul V SeniorSteven T F Chan
Apr 22, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Daniel BexellJohan Bengzon

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Citations

Sep 2, 2014·Nature Reviews. Cancer·Daniel W Stuckey, Khalid Shah
Apr 29, 2014·Journal of Cancer Research and Clinical Oncology·Ke-Tai GuoChristian Schichor
Dec 17, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Micheli M PillatHenning Ulrich
Dec 22, 2016·Biological Chemistry·Barbara BreznikTamara Lah Turnšek
Apr 20, 2018·Molecular & Cellular Proteomics : MCP·Wei WuAlbert J R Heck
Jan 30, 2014·Cellular and Molecular Neurobiology·Dobroslav KyurkchievStanimir Kyurkchiev
Aug 6, 2019·Stem Cells·Sanam L Kavari, Khalid Shah
Oct 1, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Vashendriya V V HiraCornelis J F Van Noorden
Aug 20, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Mona N OliveiraTamara T Lah
May 17, 2018·Oncotarget·Camila Ramalho BonturiMaria Luiza Vilela Oliva
Nov 2, 2017·Oncotarget·Cheng-Liang ZhangDong Liu
Jun 18, 2020·International Journal of Molecular Sciences·Metka NovakTamara Lah Turnšek
Feb 28, 2014·Oncology Reports·Yongsheng ZhangWen G Jiang
Mar 17, 2015·Advanced Healthcare Materials·Perry T YinKi-Bum Lee
Jun 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Camila Ramalho BonturiMaria Luiza Vilela Oliva
Jan 14, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Micheli Mainardi PillatHenning Ulrich
Oct 16, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Bahar Yetkin-ArikCornelis J F van Noorden

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Datasets Mentioned

BETA
GSE26283

Methods Mentioned

BETA
Assay
Antibody Array
X-ray
PCR

Software Mentioned

BioMine search
limma
GOStats Bioconductor
Bioconductor
Studio
GO
annotate
BioMine
lumi
R

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