Human mesenchymal stem cells in spheroids improve fertility in model animals with damaged endometrium

Stem Cell Research & Therapy
Alisa DomninaNikolay Nikolsky

Abstract

Asherman's syndrome (AS) is one of the gynecological disorders caused by the destruction of the endometrium. For some cases of AS available surgical methods and hormonal therapy are ineffective. Stem cell transplantation may offer a potential alternative for AS cure. Human endometrial mesenchymal stem cells (eMSC) organized in spheroids were transplanted in rats with damaged endometrium modeled on AS. Treatment response was defined as pregnancy outcome and litter size. Application of eMSC in spheroids significantly improved the rat fertility with the AS model. eMSC organized in spheroids retain all properties of eMSC in monolayer: growth characteristics, expression of CD markers, and differentiation potential. Synthesis of angiogenic and anti-inflammatory factors drastically increased in eMSC assembled into spheroids. Human endometrial mesenchymal stem cells (eMSC) can be successfully applied for Asherman's syndrome (AS) treatment in the rat model. eMSC organized in spheroids were more therapeutically effective than the cells in monolayer. After transplantation of eMSC in spheroids the pregnancy outcome and litter size in rats with AS was higher than in rats that received autologous rat bone marrow cells. It suggests the therap...Continue Reading

References

Dec 14, 1985·British Medical Journal·M G HullK M Desai
Feb 18, 2004·Fertility and Sterility·Nam Hoon ChoSei Kwang Kim
May 18, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Caroline E Gargett
May 19, 2006·Expert Opinion on Biological Therapy·Anna M Parker, Adam J Katz
Jan 9, 2007·Nature Biotechnology·Paolo De CoppiAnthony Atala
Mar 29, 2008·Cell Stem Cell·Stefanie LiedtkeGesine Kögler
Apr 15, 2008·Fertility and Sterility·Dan YuTin-Chiu Li
Aug 21, 2008·Journal of Translational Medicine·Michael P MurphyNeil H Riordan
Feb 24, 2009·Journal of Translational Medicine·Zhaohui ZhongBoris Minev
Jun 23, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elke KunischRaimund W Kinne
Jul 27, 2010·Journal of Minimally Invasive Gynecology·Rebecca Deans, Jason Abbott
Aug 19, 2010·Journal of Cellular and Molecular Medicine·Darwin J ProckopRoxanne L Reger
May 10, 2011·Reproductive Biomedicine Online·Charles M March
Aug 1, 2012·Reviews in Endocrine & Metabolic Disorders·Caroline E GargettLouie Ye
Nov 6, 2013·Journal of Cellular and Molecular Medicine·Nicolas EspagnollePhilippe Bourin
Jun 30, 2014·Journal of Assisted Reproduction and Genetics·Sevtap KilicT Delibasi
Aug 7, 2014·Journal of Biological Engineering·Javad VerdiAlexander M Seifalian
Sep 6, 2014·Journal of Human Reproductive Sciences·Neeta SinghSona Dharmendra
Jul 4, 2015·Cell Stem Cell·Alan Trounson, Courtney McDonald
Dec 10, 2015·Stem Cells International·Zoe Cesarz, Kenichi Tamama
Apr 28, 2017·Stem Cell Research & Therapy·Yuriy PetrenkoŠárka Kubinová

❮ Previous
Next ❯

Citations

Feb 6, 2019·Cellular and Molecular Life Sciences : CMLS·Yanli LiuNan Ma
Feb 15, 2019·Current Stem Cell Research & Therapy·Xuejing HouNicola Pluchino
May 24, 2020·Journal of Assisted Reproduction and Genetics·Ariel BenorAlan DeCherney
Jun 20, 2020·Reproductive Biology and Endocrinology : RB&E·Heidar Heidari-KhoeiHossein Baharvand
Jan 25, 2019·Stem Cells International·L L AlekseenkoN N Nikolsky
Jul 19, 2020·Stem Cell Reviews and Reports·Aleksandra JaukovićMilena Mourdjeva
Jun 5, 2020·Cell Death and Differentiation·Lama AlzamilMargherita Y Turco
Dec 19, 2020·International Journal of Molecular Sciences·Rosana de Almeida SantosRegina Coeli Dos Santos Goldenberg
Jan 9, 2021·Stem Cell Research & Therapy·Mesude BicerDarius Widera
Oct 15, 2020·Cells·Sahar EsfandyariAyman Al-Hendy
Sep 16, 2020·Cancer Treatment Reviews·Anita SemertzidouMaria Kyrgiou
May 21, 2021·Molecular Reproduction and Development·Qiaoying LvXiaojun Chen
Jun 3, 2021·Journal of Personalized Medicine·Alisa DomninaNikolay Nikolsky
Jun 10, 2021·Cell Transplantation·Yiyin GaoLianwen Zheng
Jul 3, 2021·Cells·Sarama SahaSham S Kakar

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
FCS
ELISA
PCR
electrophoresis
light microscopy
flow cytometry

Software Mentioned

SPSS Statistics

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Godis̆en Zbornik Na Medicinskiot Fakultet Vo Skopje
M LazarevskiG Adamova
Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology
J AbbottThierry G Vancaillie
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Liang LiangTingbo Liang
© 2022 Meta ULC. All rights reserved