Jul 26, 2015

Human metabolic atlas: an online resource for human metabolism

Database : the Journal of Biological Databases and Curation
Natapol PornputtapongJens Nielsen

Abstract

Human tissue-specific genome-scale metabolic models (GEMs) provide comprehensive understanding of human metabolism, which is of great value to the biomedical research community. To make this kind of data easily accessible to the public, we have designed and deployed the human metabolic atlas (HMA) website (http://www.metabolicatlas.org). This online resource provides comprehensive information about human metabolism, including the results of metabolic network analyses. We hope that it can also serve as an information exchange interface for human metabolism knowledge within the research community. The HMA consists of three major components: Repository, Hreed (Human REaction Entities Database) and Atlas. Repository is a collection of GEMs for specific human cell types and human-related microorganisms in SBML (System Biology Markup Language) format. The current release consists of several types of GEMs: a generic human GEM, 82 GEMs for normal cell types, 16 GEMs for different cancer cell types, 2 curated GEMs and 5 GEMs for human gut bacteria. Hreed contains detailed information about biochemical reactions. A web interface for Hreed facilitates an access to the Hreed reaction data, which can be easily retrieved by using specific ke...Continue Reading

  • References33
  • Citations16

Mentioned in this Paper

Microorganism
Metabolic Process, Cellular
3-hydroxymugineic acid
Surface of Atlas
Research
Genetically Engineered Mouse
Genes
Metabolic Networks
Gut bacterium 2 of Coptotermes formosanus
Gem protein, mouse

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