PMID: 6984012Jan 1, 1982Paper

Human MHC class II molecules as differentiation markers

Immunogenetics
V van HeyningenC M Steel

Abstract

DA6.231 and DA6.164 are mouse monoclonal antibodies that immunoprecipitate HLA-DR-like p34,29 glycoprotein dimers from surface- and metabolically-labeled cells. On lymphoblastoid cell lines the distribution of the 231 epitope is completely nonpolymorphic, while the 164 epitope is present on all cells except on those that are DR7 homozygous. Binding-inhibition studies show that the 231 and 164 epitopes are spatially close to each other when present on the same molecule. The mutual inhibition pattern and the absence of the 164 epitope from the 231+ cells of a few leukemia patients suggest, however, that 231 and 164 epitopes are not invariably present together. Most DR-positive cells possess 231+ and 164+ and 231+ 164- class II molecules in approximately a 2:1 ratio. This has been confirmed by immune depletion studies. Thus DA6.231 appears to define a supralocus epitope. The 164 epitope may be a marker for a subset of class II molecules exhibiting differential expression on various cell types immortalized by malignant transformation.

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Citations

May 1, 1987·Journal of Reproductive Immunology·P M Starkey
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R PalaciosK Guy
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R Palacios
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J A YoungJ Trowsdale
May 1, 1990·The British Journal of Dermatology·S E KellyS Fleming
Oct 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J M HeyesJ G Bodmer
Oct 1, 1991·Annals of the Rheumatic Diseases·E HermannK H Meyer zum Büschenfelde
Jun 1, 1989·The British Journal of Dermatology·S E KellyM M Black
Dec 1, 1985·European Journal of Immunology·J P FermandJ C Brouet
Apr 1, 1984·Scandinavian Journal of Immunology·G BrownC M Steel
Aug 1, 1985·The Journal of Pathology·I A LampertL K Borysiewicz
Oct 15, 1986·International Journal of Cancer. Journal International Du Cancer·A K GhoshP F Schofield
Jan 1, 1990·Scandinavian Journal of Rheumatology·E HermannB Fleischer
Feb 1, 1988·Journal of Endocrinological Investigation·U Di MarioD Andreani
May 1, 1989·European Journal of Haematology·M R PadrósL Fainboim

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