Human Milk Components Modulate Toll-Like Receptor-Mediated Inflammation

Advances in Nutrition
YingYing HeDavid S Newburg

Abstract

Toll-like receptor (TLR) signaling is central to innate immunity. Aberrant expression of TLRs is found in neonatal inflammatory diseases. Several bioactive components of human milk modulate TLR expression and signaling pathways, including soluble toll-like receptors (sTLRs), soluble cluster of differentiation (sCD) 14, glycoproteins, small peptides, and oligosaccharides. Some milk components, such as sialyl (α2,3) lactose and lacto-N-fucopentaose III, are reported to increase TLR signaling; under some circumstances this might contribute toward immunologic balance. Human milk on the whole is strongly anti-inflammatory, and contains abundant components that depress TLR signaling pathways: sTLR2 and sCD14 inhibit TLR2 signaling; sCD14, lactadherin, lactoferrin, and 2'-fucosyllactose attenuate TLR4 signaling; 3'-galactosyllactose inhibits TLR3 signaling, and β-defensin 2 inhibits TLR7 signaling. Feeding human milk to neonates decreases their risk of sepsis and necrotizing enterocolitis. Thus, the TLR regulatory components found in human milk hold promise as benign oral prophylactic and therapeutic treatments for the many gastrointestinal inflammatory disorders mediated by abnormal TLR signaling.

References

Apr 1, 1991·Archives of Disease in Childhood·R N AshrafL A Hanson
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·P Velupillai, D A Harn
May 8, 1999·The American Journal of Clinical Nutrition·J J Cebra
Jun 11, 1999·The Journal of Biological Chemistry·R SchwandnerC J Kirschning
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·N N NanthakumarW A Walker
Jan 15, 2002·Advances in Experimental Medicine and Biology·E S Buescher
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·N Nanda NanthakumarW Allan Walker
Dec 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·W McGuire, M Y Anthony
Feb 4, 2003·Nature Reviews. Immunology·Bruce Beutler, Ernst Th Rietschel
Mar 27, 2003·Cellular Immunology·Liliana HåversenInger Mattsby-Baltzer
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Morihito SatoYoshio Kuroki
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul G ThomasDonald A Harn
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanuel LeBouderMario O Labéta
Feb 21, 2004·Science·Sandra S DieboldCaetano Reis e Sousa
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Apr 15, 2005·Molecular Immunology·Elke Cario, Daniel K Podolsky
Jul 14, 2005·Annual Review of Nutrition·David S NewburgArdythe L Morrow
Aug 9, 2005·Seminars in Pediatric Surgery·Michael S CaplanTamas Jilling
Sep 29, 2005·Pediatric Research·Dorothee ViemannJohannes Roth
Oct 22, 2005·The Journal of Clinical Investigation·Marloes A NaardingWilliam A Paxton
Nov 2, 2005·Cellular and Molecular Life Sciences : CMLS·D LegrandJ Mazurier
Dec 24, 2005·International Immunology·Masahito HashimotoYasuo Suda
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanuel LeBouderMario O Labéta
Mar 15, 2006·Nutrition·Gabriele SchumacherChristopher Beermann
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tamas JillingMichael S Caplan
Jan 11, 2007·Pediatric Research·David S Newburg, W Allan Walker
Mar 17, 2007·Clinical Chemistry·Miloslav KverkaHelena Tlaskalova-Hogenova
Apr 26, 2007·Nature Reviews. Immunology·Ofer Levy
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cynthia L LeaphartDavid J Hackam
Feb 29, 2008·Cytokine·Yong-Chen LuPamela S Ohashi

❮ Previous
Next ❯

Citations

Jun 25, 2016·Expert Reviews in Molecular Medicine·Steven X ChoMarcel F Nold
Aug 18, 2017·Nutrients·Daniel MunblitJohn O Warner
Nov 23, 2017·Frontiers in Immunology·Marian L KruzelJeffrey K Actor
Aug 11, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shujuan Chen, Robert H Tukey
Mar 13, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Thea Magrone, Emilio Jirillo
Nov 6, 2018·Current Pediatric Reviews·Catalina Bazacliu, Josef Neu
Oct 31, 2019·British Journal of Pharmacology·Yang CaiSaskia Braber
May 14, 2020·The American Journal of Clinical Nutrition·Victor D Torres RoldanTheresa J Ochoa
Sep 12, 2020·Critical Reviews in Food Science and Nutrition·Emmanuel Pérez-EscalanteLuis Guillermo González-Olivares
Sep 27, 2018·Frontiers in Pediatrics·Veronica Ayechu-MuruzabalBelinda Van't Land
Nov 9, 2018·Frontiers in Cellular and Infection Microbiology·Ignasi Azagra-BoronatFrancisco J Pérez-Cano
Feb 7, 2019·Frontiers in Immunology·Bassel Dawod, Jean S Marshall
Jun 15, 2017·Frontiers in Immunology·Nicole Theresa Cacho, Robert M Lawrence
Aug 14, 2019·Cells·Ignasi Azagra-BoronatMaria J Rodríguez-Lagunas
Mar 17, 2018·Frontiers in Immunology·Piera ValentiPaola Mastromarino
Aug 24, 2018·Molecular Medicine·Naomi-Liza Denning, Jose M Prince
Feb 9, 2017·Proceedings of the National Academy of Sciences of the United States of America·Shujuan ChenRobert H Tukey
Dec 31, 2019·Journal of Immunology Research·Chiara CattaneoMaria Cavaletto
Jun 24, 2020·Frontiers in Immunology·Douglas B KellEtheresia Pretorius
Apr 4, 2020·Current Pharmaceutical Design·Rita Del PintoDavide Grassi
Feb 14, 2021·Physiological Reports·Aline Vasques da CostaPatrícia Gama
Feb 2, 2021·Gastroenterology Clinics of North America·Joann Romano-KeelerJun Sun
Jan 12, 2021·Seminars in Perinatology·Amy D BurrisKirsi M Järvinen
Mar 10, 2021·Critical Reviews in Food Science and Nutrition·Michał SienkiewiczJakub Fichna
Aug 21, 2020·Asian-Australasian Journal of Animal Sciences·Ahmed M Sallam
Apr 4, 2021·Microorganisms·Sophie I S Wedekind, Natalie S Shenker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

© 2022 Meta ULC. All rights reserved