Human Milk Lipidomics: Current Techniques and Methodologies

Nutrients
Alexandra D GeorgeDonna T Geddes

Abstract

Human milk contains a complex combination of lipids, proteins, carbohydrates, and minerals, which are essential for infant growth and development. While the lipid portion constitutes only 5% of the total human milk composition, it accounts for over 50% of the infant's daily energy intake. Human milk lipids vary throughout a feed, day, and through different stages of lactation, resulting in difficulties in sampling standardization and, like blood, human milk is bioactive containing endogenous lipases, therefore appropriate storage is critical in order to prevent lipolysis. Suitable sample preparation, often not described in studies, must also be chosen to achieve the aims of the study. Gas chromatography methods have classically been carried out to investigate the fatty acid composition of human milk lipids, but with the advancement of other chromatographic techniques, such as liquid and supercritical fluid chromatography, as well as mass spectrometry, intact lipids can also be characterized. Despite the known importance, concise and comprehensive analysis of the human milk lipidome is limited, with gaps existing in all areas of human milk lipidomics, discussed in this review. With appropriate methodology and instrumentation, fu...Continue Reading

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Citations

Dec 12, 2019·Expert Review of Proteomics·Flaminia BardanzelluAlessandra Coscia
Feb 20, 2020·Maternal & Child Nutrition·Lindsay EllsworthBrigid Gregg
Apr 3, 2020·The Journal of Nutrition·Gabriela E LeghiBeverly S Muhlhausler
Apr 23, 2020·Nutrients·Magdalena Orczyk-Pawiłowicz, Jolanta Lis-Kuberka
Apr 12, 2019·Nutrients·Donna Geddes, Sharon Perrella
Jan 26, 2020·Metabolites·Isabel Ten-DoménechGuillermo Quintás
Mar 3, 2019·Nutrients·Marie-Cécile Alexandre-GouabauClair-Yves Boquien
Jun 23, 2019·BMC Pregnancy and Childbirth·Alexandra D GeorgeDonna T Geddes
Jan 17, 2020·Scientific Reports·Tereza PavlovaJulie Bienertova-Vasku
Mar 18, 2021·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·George Stratigopoulos
Jun 8, 2021·International Journal of Food Science·Cristine Couto AlmeidaCarlos Adam Conte-Junior
Jul 7, 2021·Molecular Nutrition & Food Research·Shilong JiangKaifeng Li
Sep 25, 2018·Journal of Agricultural and Food Chemistry·Dorota GarwolińskaWeronika Hewelt-Belka

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Methods Mentioned

BETA
nuclear magnetic resonance
Fluid
NMR

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