Human milk microbiota associated with early colonization of the neonatal gut in Mexican newborns

PeerJ
Karina Corona-CervantesJaime García-Mena

Abstract

Human milk microbiota plays a role in the bacterial colonization of the neonatal gut, which has important consequences in the health and development of the newborn. However, there are few studies about the vertical transfer of bacteria from mother to infant in Latin American populations. We performed a cross-sectional study characterizing the bacterial diversity of 67 human milk-neonatal stool pairs by high-throughput sequencing of V3-16S rDNA libraries, to assess the effect of the human milk microbiota on the bacterial composition of the neonate's gut at early days. Human milk showed higher microbial diversity as compared to the neonatal stool. Members of the Staphylococcaceae and Sphingomonadaceae families were more prevalent in human milk, whereas the Pseudomonadaceae family, Clostridium and Bifidobacterium genera were in the neonatal stool. The delivery mode showed association with the neonatal gut microbiota diversity, but not with the human milk microbiota diversity; for instance, neonates born by C-section showed greater richness and diversity in stool microbiota than those born vaginally. We found 25 bacterial taxa shared by both ecosystems and 67.7% of bacteria found in neonate stool were predicted to originate from hu...Continue Reading

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Citations

Jan 26, 2021·Journal of Alzheimer's Disease : JAD·Daniel Cuervo-ZanattaClaudia Perez-Cruz
Apr 29, 2021·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Igrid García-GonzálezJaime García-Mena
Nov 23, 2021·Frontiers in Immunology·Erick Sánchez-SalgueroLeopoldo Santos-Argumedo

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Datasets Mentioned

BETA
J01859.1
PRJNA548324

Methods Mentioned

BETA
PCR
Chip

Software Mentioned

Bioinformatics and Evolutionary Genomics
Adonis
ANOSIM
Statistical Analysis of Taxonomic and Function
QIIME ( Quantitative Insights into Microbial Ecology )
STAMP
QIIME pipeline
Trimmomatic
ggplot2
RColorBrewer

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