Human Milk Oligosaccharide Composition Is Associated With Excessive Weight Gain During Exclusive Breastfeeding-An Explorative Study

Frontiers in Pediatrics
Melanie W LarssonLars Bode

Abstract

Background: Some infants experience excessive weight gain during exclusive breastfeeding. The cause is unknown, but variation in human milk composition might play a role. Several human milk koligosaccharides (HMOs) have been associated with growth velocity in breastfed infants, and it has been suggested that the mechanism could be through an effect on infant gut microbiota composition. Objective: The purpose of this exploratory study was to evaluate if HMO composition was different in milk fed to infants with excessive weight gain compared to infants with normal weight gain. Furthermore, we aimed to examine if HMO composition was associated with growth velocity and change in body composition and if there were maternal determinants of HMO composition. Materials and Methods: We recruited 13 high weight-gain (HW) and 17 normal weight-gain (NW) breastfed infants, collected human milk and anthropometry data at 5 and 9 months, and analyzed HMO composition by high performance liquid chromatography. Results: In the HW group eight out of 11 infants received milk from secretor mothers and in the NW group 15 out of 17. Comparing milk from Secretor mothers only, four HMO's were significantly different between the HW and NW group at 5 month...Continue Reading

References

Feb 1, 1984·The Journal of Pediatrics·N F ButteB L Nichols
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Dec 22, 2006·Nature·Peter J TurnbaughJeffrey I Gordon
Dec 25, 2008·The Journal of Nutrition·Michael S KramerStanley Shapiro
May 16, 2012·Advances in Nutrition·Silvia Rudloff, Clemens Kunz
Oct 11, 2014·Annals of Nutrition & Metabolism·Maria GrunewaldBerthold Koletzko
Feb 5, 2015·Journal of Pediatric Gastroenterology and Nutrition·Mei WangSharon M Donovan
Jun 6, 2015·Archives of Disease in Childhood·Esmee M van der WillikJoana Kist-van Holthe
Jul 15, 2015·Journal of Pediatric Gastroenterology and Nutrition·Barbara J MarriageJennifer A Williams
Oct 17, 2015·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Sharon Lisa Perrella, Donna Tracy Geddes
Oct 30, 2015·The American Journal of Clinical Nutrition·Tanya L AldereteDavid A Fields
Feb 13, 2016·Lancet·Cesar G VictoraUNKNOWN Lancet Breastfeeding Series Group
Jan 21, 2017·Journal of Pediatric Gastroenterology and Nutrition·Giuseppe PuccioPhilippe Steenhout
Jun 9, 2017·Journal of Pediatric Endocrinology & Metabolism : JPEM·Carola SaureCarmen Silvia Mazza
Feb 21, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Kamilla G EriksenKim F Michaelsen
Mar 16, 2018·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Melanie Wange LarssonKim F Michaelsen
Jul 11, 2018·Nestlé Nutrition Institute Workshop Series·Mads Vendelbo LindKim F Michaelsen
Oct 26, 2018·Nature·Christopher J StewartJoseph F Petrosino
Oct 31, 2018·Nature Medicine·Aimee M Baumann-DudenhoefferGautam Dantas

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Citations

Mar 20, 2020·FEMS Microbiology Ecology·Gabriele Andrea LugliMarco Ventura
Apr 19, 2020·Current Opinion in Clinical Nutrition and Metabolic Care·Paige K BergerDavid A Fields
Aug 15, 2020·Frontiers in Immunology·Flaminia BardanzelluVassilios Fanos
Feb 6, 2021·Nutrients·Elvira VerduciGian Vincenzo Zuccotti
Mar 12, 2021·The Journal of Nutrition·Jasmine F PlowsMichael I Goran
Feb 26, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Wei Wei Pang, Keri McCrickerd
Apr 30, 2021·Frontiers in Immunology·Lieke W J van den Elsen, Valerie Verhasselt
Jun 11, 2021·Expert Review of Proteomics·Flaminia BardanzelluVassilios Fanos
Nov 7, 2021·Analytical and Bioanalytical Chemistry·Saeromi ChungDrew A Hall

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