Human minisatellite loci composed of interspersed GGA-GGT triplet repeats

Proceedings. Biological Sciences
J A ArmourA J Jeffreys

Abstract

We have isolated two tandemly repeated loci from human DNA which contain long blocks of GGA and GGT trinucleotide repeats. These two repeat unit types, together with other less common variants, are apparently irregularly interspersed along each repeat array. Genotyping methods have been developed for these highly polymorphic loci, including typing by polymerase chain reaction followed by Southern blot hybridization. Linkage analysis in Centre d'Etude du Polymorphisme Humain (CEPH) pedigrees has been used to map the loci to chromosomes 15 and 22. In normal individuals, alleles at these loci can contain thousands of repeats, greatly exceeding repeat copy number at most trinucleotide and other simple repeat loci. No evidence for longer, higher-order repeats was observed among the limited number of repeats sequenced. These loci may represent a transitional state between simple repeat loci and some minisatellites.

References

Oct 29, 1992·Nature·J WeissenbachM Lathrop
Jan 1, 1992·Genomics·J A ArmourA J Jeffreys
Dec 1, 1991·Current Opinion in Genetics & Development·H F Willard
Aug 25, 1991·Nucleic Acids Research·Y NakahoriD Bentley
Feb 1, 1989·Journal of Medical Genetics·M PembreyM Super
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Saito, G R Stark
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
Oct 1, 1987·Annals of Human Genetics·Z WongA J Jeffreys
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·W M Barnes
Jun 11, 1993·Nucleic Acids Research·H M BreretonD R Turner

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Citations

Dec 22, 1999·Nucleic Acids Research·J A ArmourG Cross
Aug 5, 1998·Nature·E N SignerM Peaker
Apr 4, 1997·The Journal of Biological Chemistry·M N WeitzmannK Usdin

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