PMID: 9543345Jun 6, 1998Paper

Human mitochondrial function during cardiac growth and development

Molecular and Cellular Biochemistry
José Marín-GarcíaMichael J Goldenthal

Abstract

Little information is presently available concerning mitochondrial respiratory and oxidative phosphorylation function in the normal human heart during growth and development. We investigated the levels of specific mitochondrial enzyme activities and content during cardiac growth and development from the early neonatal period (10-20 days) to adulthood (67 years). Biochemical analysis of enzyme specific activities and content and mitochondrial DNA (mtDNA) copy number was performed with left ventricular tissues derived from 30 control individuals. The levels of cytochrome c oxidase (COX) and complex V specific activity, mtDNA copy number and COX subunit II content remained unchanged in contrast to increased citrate synthase (CS) activity and content. The developmental increase in CS activity paralleled increasing CS polypeptide content, but was neither related to overall increases in mitochondrial number nor coordinately regulated with mitochondrial respiratory enzyme activities. Our findings of unchanged levels of cardiac mitochondrial respiratory enzyme activity during the progression from early childhood to older adult contrasts with the age-specific regulation found with CS, a Krebs cycle mitochondrial enzyme.

Citations

Feb 5, 2009·The New Phytologist·Gianpiero ViganiGraziano Zocchi
Apr 9, 2009·Journal of Bioenergetics and Biomembranes·H Lemieux, C L Hoppel
Oct 3, 2009·Journal of Enzyme Inhibition and Medicinal Chemistry·Nikolai L ChepelevWilliam G Willmore
Feb 18, 2004·Aging Cell·Elena Maklashina, Brian A C Ackrell
Feb 21, 2014·ISRN Obesity·Martine ChristePeter W Lindinger
Aug 31, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Hélène LemieuxCharles L Hoppel
Jul 18, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M CapkováJ Zeman
Oct 13, 2020·Mechanisms of Ageing and Development·Jeremy ThompsonQun Chen
Apr 3, 2020·Journal of Molecular and Cellular Cardiology·Aleksandr B StotlandSarah J Parker
Feb 18, 2004·Journal of Cardiac Failure·José Marín-García, Michael J Goldenthal
Mar 12, 2008·Free Radical Biology & Medicine·Kashyap B Choksi, John Papaconstantinou
Jul 13, 2013·Trends in Endocrinology and Metabolism : TEM·Yael YanivSteven J Sollott

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