PMID: 6976416Jan 1, 1982Paper

Human monoclonal anti-keyhole limpet hemocyanin antibody-secreting hybridoma produced from peripheral blood B lymphocytes of a keyhole limpet hemocyanin-immune individual

The Journal of Experimental Medicine
H C LaneA S Fauci

Abstract

A human IgMk monoclonal antibody, 2F7, of predetermined specificity, has been produced by the fusion of human peripheral blood lymphocytes with the nonsecreting mouse myeloma line SP-1. The heterohybridoma has remained stable for over 8 mo, with culture supernatants containing up to 30 micrograms/ml of specific IgM. The antibody has been shown to be capable of inducing a blastogenic response in the absence of antigen in the peripheral blood lymphocytes of normal subjects immune to the antigen. The ability to choose an antigen, immunize a human subject to that antigen, and then use the peripheral blood lymphocytes from that subject to produce antigen-specific human monoclonal antibodies should be of great value in a wide variety of investigative, diagnostic, and therapeutic endeavors.U

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Citations

Jun 24, 1983·Journal of Immunological Methods·L OlssonB Jakobsen
Aug 2, 1985·Journal of Immunological Methods·L MayerH G Kunkel
Dec 17, 1985·Journal of Immunological Methods·J Lagacé, B R Brodeur
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Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J W LarrickJ C Wang
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·N N TengH S Kaplan
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J CoteL J Old
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Jan 1, 1984·Medical Oncology and Tumor Pharmacotherapy·A M NevilleM J O'Hare

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