Human monocytes and lymphocytes produce different mixtures of alpha-interferon subtypes

Journal of Interferon Research
T GorenM Rubinstein

Abstract

alpha-Interferon (IFN-alpha) was produced by either peripheral blood lymphocytes or by monocytes and purified by an anti-IFN-alpha affinity column. When these preparations were analyzed by reversed-phase HPLC, a difference in the distribution of IFN-alpha subtypes from the two cell types was found. While the two major subtypes of IFN from induced lymphocytes had apparent molecular weights of 20K and 21K, monocytes produce an additional subtype of molecular weight 26K in large quantities (50%). This subtype had greater activity on human cells than on bovine cells in comparison to other IFN-alpha subtypes.

References

Dec 4, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J HiscottC Weissmann
Feb 1, 1981·Journal of Virology·S RubinsteinS Pestka
Aug 1, 1981·Archives of Biochemistry and Biophysics·M RubinsteinS Pestka
Feb 1, 1981·Journal of Interferon Research·M Wiranowska-Stewart, W E Stewart
Apr 1, 1984·The Journal of General Virology·H KikutaT Osato
May 11, 1984·Nucleic Acids Research·J HiscottC Weissmann
Jul 1, 1984·Archives of Biochemistry and Biophysics·J E LabdonS Pestka
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J R OrtaldoS Pestka

❮ Previous
Next ❯

Citations

Apr 14, 1995·Neuroscience Letters·T Yamada, I Yamanaka
Apr 1, 1994·British Journal of Haematology·E R BrandtR J Devenish
Sep 1, 1995·Medicinal Research Reviews·G C ViscomiS Silvestri
Oct 1, 1987·Journal of Interferon Research·M Rubinstein
Oct 1, 1987·Journal of Interferon Research·K Cantell
Oct 1, 1996·The Pediatric Infectious Disease Journal·F MoulinD Gendrel
May 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·C M LawsonM W Beilharz
Sep 23, 2011·Molecular Biology Reports·Muhammad Sarwar Khan, Farwa Nurjis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.