Human Motor Thalamus Reconstructed in 3D from Continuous Sagittal Sections with Identified Subcortical Afferent Territories

ENeuro
Igor IlinskyKristy Kultas-Ilinsky

Abstract

Classification and delineation of the motor-related nuclei in the human thalamus have been the focus of numerous discussions for a long time. Difficulties in finding consensus have for the most part been caused by paucity of direct experimental data on connections of individual nuclear entities. Kultas-Ilinsky et al. (2011) showed that distribution of glutamic acid decarboxylase isoform 65 (GAD65), the enzyme that synthesizes inhibitory neurotransmitter γ-aminobutyric acid, is a reliable marker that allows to delineate connectionally distinct nuclei in the human motor thalamus, namely the territories innervated by nigral, pallidal, and cerebellar afferents. We compared those immunocytochemical staining patterns with underlying cytoarchitecture and used the latter to outline the three afferent territories in a continuous series of sagittal Nissl-stained sections of the human thalamus. The 3D volume reconstructed from the outlines was placed in the Talairach stereotactic coordinate system relative to the intercommissural line and sectioned in three stereotactic planes to produce color-coded nuclear maps. This 3D coordinate-based atlas was coregistered to the Montreal Neurological Institute (MNI-152) space. The current report prop...Continue Reading

Citations

Aug 24, 2019·Brain Structure & Function·Jonas A HospM Reisert
Sep 7, 2019·Acta Neuropathologica Communications·Whitney C McFaddenAndrew T McKenzie
Jan 21, 2020·Human Brain Mapping·Veronica CoronaJulio Acosta-Cabronero
Jan 29, 2019·Frontiers in Neuroanatomy·Jürgen K Mai, Milan Majtanik
Oct 29, 2020·Human Brain Mapping·Jonas Aurel HospCornelius Weiller
Mar 8, 2019·Current Opinion in Neurology·Andreas Horn
Dec 29, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Shervin RahimpourDoris D Wang
Apr 28, 2021·Brain : a Journal of Neurology·Clemens NeudorferAndres M Lozano
Jul 24, 2021·Cerebral Cortex·Gianpaolo Antonio BasileAlberto Cacciola
Aug 7, 2021·Journal of Neurosurgery·Takashi MorishitaTooru Inoue

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Methods Mentioned

BETA
imaging techniques

Software Mentioned

MATLAB
Advanced Normalization Tools ( ANTs
- DBS
Slicer
Lead
Amira
Adobe Illustrator
ANTs
ITK
MNI

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