Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes

Biochemical and Biophysical Research Communications
Reiko IidaKoichiro Kishi

Abstract

M-LP (Mpv17-like protein) is a protein that was initially identified in mouse tissues and shows high sequence homology with Mpv17 protein, a peroxisomal membrane protein involved in the development of early-onset glomerulosclerosis [R. Iida, T. Yasuda, E. Tsubota, H. Takatsuka, M. Masuyama, T. Matsuki, K. Kishi, M-LP, Mpv17-like protein, has a peroxisomal membrane targeting signal comprising a transmembrane domain and a positively charged loop and up-regulates expression of the manganese superoxide dismutase gene, J. Biol. Chem. 278 (2003) 6301-6306]. Here we report the identification and characterization of a human homolog of the M-LP (M-LPH) gene. The M-LPH gene is composed of four exons, extends over 14kb on chromosome 16p13.1, and is expressed as two alternatively spliced variants comprising four and three exons, respectively, which include open-reading frames encoding two distinct isoforms composed of 196 (M-LPH1) and 147 (M-LPH2) amino acids, respectively. These two variants were expressed ubiquitously in human tissues, however only M-LPH1 was detected at the protein level. Dual-color confocal analysis of COS-7 cells transfected with a green fluorescent protein-tagged M-LPH1 demonstrated that M-LPH1 is localized in peroxi...Continue Reading

References

Jan 25, 1985·Science·P A Cerutti
Dec 22, 1995·The Journal of Biological Chemistry·V J Thannickal, B L Fanburg
Jan 1, 1996·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·A M Meyer zum GottesbergeH Weiher
Mar 28, 2003·Biochemical and Biophysical Research Communications·Dan Luo, Thomas A Rando
Jul 1, 1956·Journal of Gerontology·D HARMAN
Oct 1, 2003·Nature Genetics·Nobunao WakabayashiMasayuki Yamamoto
Apr 21, 2004·The Journal of Biological Chemistry·Charlene BierlJoseph Loscalzo

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Citations

Feb 11, 2012·Cell and Tissue Research·Angela-Maria Meyer zum GottesbergeStefan Hansen
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefanie KrickErwin P Böttinger
Feb 22, 2012·Science Translational Medicine·B Nelson ChauJeremy S Duffield
Nov 26, 2009·Genome Génome / Conseil National De Recherches Canada·Charalambos MagoulasLuis Lopez de Heredia
Mar 21, 2013·Gene·Ling-Feng LuoWan-Xi Yang
Nov 6, 2008·Protein Expression and Purification·Kyoko EgawaHiroaki Kato
May 22, 2009·BioFactors·Nina A BonekampMichael Schrader
Dec 31, 2011·Biochimica Et Biophysica Acta·Vasily D Antonenkov, J Kalervo Hiltunen
Oct 13, 2006·Biochimica Et Biophysica Acta·Michael Schrader, H Dariush Fahimi
Jun 21, 2014·Nucleic Acids Research·Ilaria Dalla RosaAntonella Spinazzola
Dec 19, 2006·The Biochemical Journal·Wouter F VisserRonald J A Wanders
Jul 6, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Reiko IidaToshihiro Yasuda

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