PMID: 8960984Oct 1, 1996Paper

Human neuroblastoma cell lines regain catecholamine fluorescence when xenografted into athymic (nude) mice

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
M M TomaykoC P Reynolds

Abstract

Detection of catecholamine production by neuroblastoma is a useful tumor marker. The majority of neuroblastoma patients have elevated levels of urinary catecholamines and/or their metabolites, and have tumors, which show histochemical evidence of catecholamines using glyoxylic acid-induced catecholamine fluorescence. By contrast, continuous cell lines derived from neuroblastomas lack catecholamine fluorescence in vitro. In this study, we report that 11 out of 12 human neuroblastoma cell lines established from catecholamine-positive tumors displayed histochemical evidence of catecholamines when grown as xenografts in athymic (nude) mice. Catecholamine fluorescence in these xenograft tumors decayed over a 5 day period when the cells were placed into tissue culture. Xenograft tumors of cell lines derived from four catecholamine-negative neuroblastomas or seven primitive neuroectodermal tumors (PNET) did not show catecholamine fluorescence. Ultrastructural comparisons of cell lines in vitro with their corresponding tumors in vivo showed that six of eight cell lines had fewer dense core (neurosecretory) granules in vitro compared to the more readily detectable dense core granules seen in nude mouse tumor tissue. These data indicate ...Continue Reading

References

May 3, 1976·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·T Nishiyama, H Okano
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Apr 1, 1986·Cancer Genetics and Cytogenetics·J Whang-PengM A Israel
Jan 1, 1987·Cancer Genetics and Cytogenetics·V R PotluriL Helson
Sep 1, 1981·Cellular and Molecular Neurobiology·R A RossD J Reis
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Mar 1, 1981·American Journal of Clinical Pathology·C P ReynoldsR G Smith
Jul 1, 1993·Seminars in Nuclear Medicine·M J Gelfand
Dec 19, 2001·Nuclear Medicine Communications·M Mitjavila

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