Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit

Nature Communications
Maria Teresa Dell'AnnoStephen M Strittmatter

Abstract

Traumatic spinal cord injury results in persistent disability due to disconnection of surviving neural elements. Neural stem cell transplantation has been proposed as a therapeutic option, but optimal cell type and mechanistic aspects remain poorly defined. Here, we describe robust engraftment into lesioned immunodeficient mice of human neuroepithelial stem cells derived from the developing spinal cord and maintained in self-renewing adherent conditions for long periods. Extensive elongation of both graft and host axons occurs. Improved functional recovery after transplantation depends on neural relay function through the grafted neurons, requires the matching of neural identity to the anatomical site of injury, and is accompanied by expression of specific marker proteins. Thus, human neuroepithelial stem cells may provide an anatomically specific relay function for spinal cord injury recovery.

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Citations

Feb 15, 2020·Artificial Cells, Nanomedicine, and Biotechnology·Jian KangGuanghui Xu
Feb 11, 2020·Advanced Functional Materials·Daeha JoungMichael C McAlpine
Aug 29, 2020·Clinical Epigenetics·Dingailu MaYujiang G Shi
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Elena MorelliThomas Vaccari
Apr 4, 2021·International Journal of Molecular Sciences·Federica AnastasiPaolo Bongioanni
Jul 25, 2021·International Journal of Molecular Sciences·Bing-Chun LiuSi-Qin Bao
Aug 15, 2021·Experimental Neurology·Valérie Van Steenbergen, Florence M Bareyre

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Datasets Mentioned

BETA
GSE107514

Methods Mentioned

BETA
transgenic

Software Mentioned

DESeq2
GENCODE
Clampfit
Zeiss Zen
R WGCNA
Adobe Photoshop
FeatureCounts
Excelitas
OriginPro
Clampex

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