Human neuromuscular aging: Sex differences revealed at the myocellular level.

Experimental Gerontology
Brandon M RobertsMarcas M Bamman

Abstract

Age-related muscle loss (sarcopenia) is a major clinical problem affecting both men and women - accompanied by muscle weakness, dysfunction, disability, and impaired quality of life. Current definitions of sarcopenia do not fully encompass the age-related changes in skeletal muscle. We therefore examined the influence of aging and sex on elements of skeletal muscle health using a thorough histopathological analysis of myocellular aging and assessments of neuromuscular performance. Two-hundred and twenty-one untrained males and females were separated into four age cohorts [mean age 25 y (n = 47), 37 y (n = 79), 61 y (n = 51), and 72 y (n = 44)]. Total (-12%), leg (-17%), and arm (-21%) lean mass were lower in both 61 y and 72 y than in 25 y or 37 y (P < 0.05). Knee extensor strength (-34%) and power (-43%) were lower (P < 0.05) in the older two groups, and explosive sit-to-stand power was lower by 37 y (P < 0.05). At the histological/myocellular level, type IIx atrophy was noted by 37 y and type IIa atrophy by 61 y (P < 0.05). These effects were driven by females, noted by substantial and progressive type IIa and IIx atrophy across age. Aged female muscle displayed greater within-type myofiber size heterogeneity and marked type ...Continue Reading

Citations

Feb 7, 2019·Physiology·Kaleen M LavinMarcas M Bamman
Aug 16, 2018·American Journal of Physiology. Cell Physiology·Emily S RiddleAnna E Thalacker-Mercer
Aug 2, 2019·The Journal of Physiology·Vita SonjakRussell T Hepple
Nov 8, 2019·Journal of Applied Physiology·Kevin A MurachMichael J Toth
Jul 30, 2019·Aging·Cory W BaumannLaDora V Thompson
Dec 13, 2019·Journal of Applied Physiology·Kaleen M LavinMarcas M Bamman
Mar 29, 2020·Journal of Strength and Conditioning Research·Brandon M RobertsJames W Krieger
Oct 16, 2020·Journal of Applied Physiology·Kaleen M LavinTodd A Trappe
May 1, 2021·International Journal of Environmental Research and Public Health·Ryan M MillerMichael G Bemben
May 12, 2021·Experimental Gerontology·Rosalia L ParrinoJoseph F Signorile
May 27, 2021·The Journal of Physiology·Gregory J GrosickiScott Trappe
Jun 13, 2021·Experimental Gerontology·Julian AlcazarCharlotte Suetta
Jul 30, 2021·Biogerontology·Alexandra Moreira-PaisJosé A Duarte
Aug 19, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giorgio VarescoVianney Rozand

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