Human neutralizing antibodies elicited by SARS-CoV-2 infection.

Bin JuLinqi Zhang


The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents a global health emergency that is in urgent need of intervention1-3. The entry of SARS-CoV-2 into its target cells depends on binding between the receptor-binding domain (RBD) of the viral spike protein and its cellular receptor, angiotensin-converting enzyme 2 (ACE2)2,4-6. Here we report the isolation and characterization of 206 RBD-specific monoclonal antibodies derived from single B cells from 8 individuals infected with SARS-CoV-2. We identified antibodies that potently neutralize SARS-CoV-2; this activity correlates with competition with ACE2 for binding to RBD. Unexpectedly, the anti-SARS-CoV-2 antibodies and the infected plasma did not cross-react with the RBDs of SARS-CoV or Middle East respiratory syndrome-related coronavirus (MERS-CoV), although there was substantial plasma cross-reactivity to their trimeric spike proteins. Analysis of the crystal structure of RBD-bound antibody revealed that steric hindrance inhibits viral engagement with ACE2, thereby blocking viral entry. These findings suggest that anti-RBD antibodies are largely viral-species-specific inhibitors. The antibodies identifi...Continue Reading


Oct 24, 2002·Acta Crystallographica. Section D, Biological Crystallography·Paul D AdamsThomas C Terwilliger
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Zhongyu ZhuDimiter S Dimitrov
Dec 21, 2007·Acta Crystallographica. Section D, Biological Crystallography·Serge X CohenAnastassis Perrakis
Feb 10, 2009·Nature Reviews. Microbiology·Lanying DuShibo Jiang
Aug 1, 2007·Journal of Applied Crystallography·Airlie J McCoyRandy J Read
Apr 5, 2013·Nature·Hua-Xin LiaoBarton F Haynes
Jun 7, 2019·Emerging Microbes & Infections·Jiuyang XuLinqi Zhang
Jan 30, 2020·The New England Journal of Medicine·Qun LiZijian Feng
Feb 23, 2020·Science·Daniel WrappJason S McLellan
Feb 29, 2020·The New England Journal of Medicine·Wei-Jie GuanUNKNOWN China Medical Treatment Expert Group for Covid-19
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler

❮ Previous
Next ❯


Jul 22, 2020·The Journal of Experimental Medicine·Fabian SchmidtPaul D Bieniasz
Jun 28, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wafaa B AlsoussiAli H Ellebedy
Aug 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tyler E MillerJochen K Lennerz
Sep 18, 2020·Expert Opinion on Therapeutic Targets·Shibo JiangLanying Du
Sep 24, 2020·Reviews in Medical Virology·Eamon O MurchuPatricia Harrington
Sep 12, 2020·Bioanalysis·Caroline Becker
Aug 6, 2020·Frontiers in Public Health·Waquar AhsanShahnaz Sultana
Aug 19, 2020·Nature Medicine·Adam G LaingAdrian C Hayday
Aug 28, 2020·Signal Transduction and Targeted Therapy·Francesca FagianiCristina Lanni
Jul 6, 2020·Nature·Gary R Whittaker, Susan Daniel
Aug 2, 2020·Nature Structural & Molecular Biology·Daming ZhouKuan-Ying A Huang
Sep 24, 2020·Signal Transduction and Targeted Therapy·Fei YuShibo Jiang
Sep 20, 2020·Science Advances·T KondoH Murakami
Aug 2, 2020·Nature Structural & Molecular Biology·Xiaoli XiongJohn A G Briggs
Sep 4, 2020·Signal Transduction and Targeted Therapy·Xiangyu ChenLilin Ye
Sep 6, 2020·Nature Communications·Leo HankeGerald M McInerney
Sep 11, 2020·Nature Microbiology·Wen Shi LeeBrandon J DeKosky
Jun 27, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Focke ZiemssenMarius Ueffing
Sep 12, 2020·Nature Reviews. Microbiology·Emmanuel MargolinEdward P Rybicki
Oct 7, 2020·Journal of Cellular Physiology·Abdolreza Esmaeilzadeh, Reza Elahi
Jul 22, 2020·Journal of Medical Virology·Yunfei WangCunbao Liu

❮ Previous
Next ❯

Methods Mentioned

enzyme-linked immunosorbent assay
surface plasmon resonance
gel filtration
Protein Assay

Software Mentioned

Clustal W
GraphPad Prism

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.