Human Neutrophil Defensin-1, -3, and -4 Are Elevated in Nasal Aspirates from Children with Naturally Occurring Adenovirus Infection

Canadian Respiratory Journal : Journal of the Canadian Thoracic Society
V S PriyadharshiniL M Teran

Abstract

Adenoviruses are highly contagious pathogens which cause respiratory disease particularly in children; they may induce severe disease in infants. Human neutrophil peptides (HNPs) have been found to exhibit antiadenoviral activity. Thus, we have investigated HNPs in nasal aspirates (NAs) of children suffering from adenoviral common cold. To investigate the release of HNP-1-4 in adenovirus infection and the relationship with self-limiting upper respiratory tract infections. Nasal aspirate samples (n=14) were obtained from children (aged 6-12 years) infected with adenovirus between June 2012 and December 2015. Control samples were taken 4 weeks after infection when the children were asymptomatic. Levels of HNPs were measured using an enzyme-linked immunosorbent assay (ELISA). There were increased levels of HNP-1, -3, and -4, but not HNP-2, in nasal aspirates (NAs) during adenovirus infections compared to healthy specimens (p ≤ 0.01). Moreover, there was also increase in the neutrophil count, which is a known cell source of HNPs. Our finding supports the involvement of HNP-1, -3, and -4 in naturally occurring cold in children infected with adenovirus. Because of their known antiviral properties, it is tempting to hypothesize that H...Continue Reading

References

Jun 1, 1979·The Journal of Pediatrics·H R HarrisonC G Ray
Apr 1, 1997·American Journal of Respiratory and Critical Care Medicine·L M TeranS T Holgate
Oct 31, 2000·The Pediatric Infectious Disease Journal·L S MitchellJ P Devincenzo
Aug 10, 2001·Regulatory Peptides·A Bastian, H Schäfer
Jan 25, 2005·The Pediatric Infectious Disease Journal·Hiroko ShikeJane C Burns
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ehsan HazratiBetsy C Herold
Jan 15, 2008·Cell Host & Microbe·Jason G Smith, Glen R Nemerow
Jun 27, 2008·The European Respiratory Journal·J SantiagoL M Terán
Mar 26, 2009·The Pediatric Infectious Disease Journal·Maria R MoroJoseph B Domachowske
Feb 2, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Eduardo Guaní-GuerraLuis M Terán
Jun 23, 2011·The Pediatric Infectious Disease Journal·Hammam GhanaiemDan Engelhard
Oct 8, 2013·Journal of Molecular Biology·Sarah S WilsonJason G Smith
Nov 16, 2013·World Journal of Pediatrics : WJP·Mei-Ping LuZhi-Min Chen
Mar 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G RohdeS L Johnston
Nov 27, 2015·Medical Hypotheses·Patrick D Shaw Stewart
Mar 5, 2016·PLoS Pathogens·Anshu P GounderJason G Smith
Mar 25, 2016·Journal of Virology·Sarah S WilsonJason G Smith
May 21, 2016·Bioscience of Microbiota, Food and Health·Kiminori NakamuraTokiyoshi Ayabe

❮ Previous
Next ❯

Citations

Sep 7, 2021·Journal of Molecular Biology·Elena KudryashovaDmitri S Kudryashov
Jan 19, 2022·Journal of Leukocyte Biology·Yuning ZhangImmanuel Kwok

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
FACS
ELISA
ELISAs

Software Mentioned

STATA

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Related Papers

The New England Journal of Medicine
Joshua D HartzellJoel C Gaydos
The New England Journal of Medicine
Daniel M Musher
Archives of Disease in Childhood
C W Allen, S I Alexander
© 2022 Meta ULC. All rights reserved