Human neutrophils degrade methacrylate resin composites and tooth dentin

Acta Biomaterialia
Russel GitalisY Finer

Abstract

Cholesterol esterase-like (CE) activity from saliva and esterase from cariogenic bacteria hydrolyze ester linkages of dental methacrylate resins. Collagenolytic, matrix metalloproteinase-like (MMP) activities from dentin and bacteria degrade collagen in demineralized tooth dentin. Human neutrophils in the oral cavity contain factors that are hypothesized to have CE and MMP activities that could contribute to the degradation of methacrylate resins and dentinal collagen. OBJECTIVES: To measure the CE and MMP activities from human neutrophils and their ability to degrade dental methacrylate resin composite and dentinal collagen. Neutrophils' CE and MMP activities were measured using nitrophenyl-esters or fluorimetric MMP substrates, respectively. Neutrophils' degradation of resin composite and dentinal collagen was quantified by measuring release of a universal 2,2-Bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (bisGMA)-derived resin composite degradation byproduct, bishydroxy-propoxy-phenyl-propane (bisHPPP), or a collagen degradation by-product, hydroxyproline, respectively using ultra performance liquid chromatography/mass spectrometry. Neutrophils' CE activity increased the release of bisHPPP from bisGMA monomer compare...Continue Reading

Citations

Aug 6, 2019·Frontiers in Neuroscience·R Dixon DorandAlex Y Huang
Jan 12, 2021·Applied Microbiology and Biotechnology·Itzel GaytánHerminia Loza-Tavera
Sep 21, 2020·Acta Biomaterialia·Russel GitalisYoav Finer
Jul 14, 2021·Journal of Public Health Dentistry·Leslie ParkCarlos Quinonez
Feb 15, 2021·Caries Research·Camila A ZamperiniAna Karina Bedran-Russo

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